Wenkui Xu1, Lei Yang1, Ying Wang1, Xiaoxia Wu1, Yong Wu2, Rong Hu3. 1. Fujian Province, The School of Nursing, Fujian Medical University, NO.1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou City, 350108, China. 2. Department of Hematology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China. wuyong9195@126.com. 3. Fujian Province, The School of Nursing, Fujian Medical University, NO.1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou City, 350108, China. ronghu1246@fjmu.edu.cn.
Abstract
PURPOSE: To investigate the effects of exercise interventions on the physical fitness, fatigue, and quality of life (QOL) in adults with hematological malignancy (HM) who did not receive hematopoietic stem cell transplantation (HSCT). METHODS: We performed a systematic review with meta-analysis and qualitative evidence synthesis. We systematically searched 10 electronic databases including Medline, Allied and Complementary Medicine Database, Cochrane Central Register of Controlled Trials, Embase, CINAHL complete, SPORTDiscus, Web of Science, China Wan Fang Database, China National Knowledge Internet, and China Science and Technology Journal Database from their inception up to March 2021. The Cochrane guideline was followed, and a PRISMA checklist for reporting systematic reviews was completed. RESULTS: Fifteen studies were included in this systematic review, of which 11 were included in the meta-analysis. There was a significant increase in the physical fitness between the exercise group and the control group, in terms of the 6-min walk test and peak oxygen consumption. There was a significant change in the peak oxygen consumption from the baseline to the endpoint in the exercise group. In the between-group analyses, there were no significant differences in the effect of exercise on the grip strength, fatigue, and QOL; however, in the within-group analysis, QOL was significantly increased in the combination exercise group. CONCLUSION: Both aerobic exercise and combination exercise appear safe and feasible and can improve physical fitness in adult patients with HM who have not received HSCT. The combination exercise may have potential benefits for their QOL.
PURPOSE: To investigate the effects of exercise interventions on the physical fitness, fatigue, and quality of life (QOL) in adults with hematological malignancy (HM) who did not receive hematopoietic stem cell transplantation (HSCT). METHODS: We performed a systematic review with meta-analysis and qualitative evidence synthesis. We systematically searched 10 electronic databases including Medline, Allied and Complementary Medicine Database, Cochrane Central Register of Controlled Trials, Embase, CINAHL complete, SPORTDiscus, Web of Science, China Wan Fang Database, China National Knowledge Internet, and China Science and Technology Journal Database from their inception up to March 2021. The Cochrane guideline was followed, and a PRISMA checklist for reporting systematic reviews was completed. RESULTS: Fifteen studies were included in this systematic review, of which 11 were included in the meta-analysis. There was a significant increase in the physical fitness between the exercise group and the control group, in terms of the 6-min walk test and peak oxygen consumption. There was a significant change in the peak oxygen consumption from the baseline to the endpoint in the exercise group. In the between-group analyses, there were no significant differences in the effect of exercise on the grip strength, fatigue, and QOL; however, in the within-group analysis, QOL was significantly increased in the combination exercise group. CONCLUSION: Both aerobic exercise and combination exercise appear safe and feasible and can improve physical fitness in adult patients with HM who have not received HSCT. The combination exercise may have potential benefits for their QOL.
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