Literature DB >> 3540943

Direct introduction of genes into rats and expression of the genes.

N Benvenisty, L Reshef.   

Abstract

A method of introducing actively expressed genes into intact mammals is described. DNA precipitated with calcium phosphate has been injected intraperitoneally into newborn rats. The injected genes have been taken up and expressed by the animal tissues. To examine the generality of the method we have injected newborn rats with the chloramphenicol acetyltransferase prokaryotic gene fused with various viral and cellular gene promoters and the gene for hepatitis B surface antigen, and we observed appearance of chloramphenicol acetyltransferase activity and hepatitis B surface antigen in liver and spleen. In addition, administration of genes coding for hormones (insulin or growth hormone) resulted in their expression.

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Year:  1986        PMID： 3540943      PMCID： PMC387178          DOI： 10.1073/pnas.83.24.9551

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development.

Authors:  N Benvenisty; D Mencher; O Meyuhas; A Razin; L Reshef
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

Review 2.  Transgenic mice.

Authors:  R D Palmiter; R L Brinster
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

3.  Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

Authors:  H Potter; L Weir; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

4.  Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression.

Authors:  I Kruczek; W Doerfler
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

5.  Direct transfection of viral and plasmid DNA into the liver or spleen of mice.

Authors:  T W Dubensky; B A Campbell; L P Villarreal
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

6.  Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.

Authors:  A Wynshaw-Boris; T G Lugo; J M Short; R E Fournier; R W Hanson
Journal:  J Biol Chem       Date:  1984-10-10       Impact factor: 5.157

7.  Prospects for human gene therapy.

Authors:  W F Anderson
Journal:  Science       Date:  1984-10-26       Impact factor: 47.728

8.  Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene.

Authors:  R E Hammer; R D Palmiter; R L Brinster
Journal:  Nature       Date:  1984 Sep 6-11       Impact factor: 49.962

Review 9.  DNA-mediated genetic transformation of mouse embryos and bone marrow--a review.

Authors:  J W Gordon; F H Ruddle
Journal:  Gene       Date:  1985       Impact factor: 3.688

Review 10.  Metallothionein-human GH fusion genes stimulate growth of mice.

Authors:  R D Palmiter; G Norstedt; R E Gelinas; R E Hammer; R L Brinster
Journal:  Science       Date:  1983-11-18       Impact factor: 47.728
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  10 in total

1.  Aerosol gene delivery in vivo.

Authors:  R Stribling; E Brunette; D Liggitt; K Gaensler; R Debs
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

Review 2.  DNA vaccines: developing new strategies to enhance immune responses.

Authors:  Shaheed A Abdulhaqq; David B Weiner
Journal:  Immunol Res       Date:  2008       Impact factor: 2.829

3.  A self-initiating eukaryotic transient gene expression system based on contransfection of bacteriophage T7 RNA polymerase and DNA vectors containing a T7 autogene.

Authors:  X Chen; Y Li; K Xiong; T E Wagner
Journal:  Nucleic Acids Res       Date:  1994-06-11       Impact factor: 16.971

4.  Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.

Authors:  R S Williams; S A Johnston; M Riedy; M J DeVit; S G McElligott; J C Sanford
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

5.  In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.

Authors:  N S Yang; J Burkholder; B Roberts; B Martinell; D McCabe
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

6.  Induction of cervical neoplasia in the mouse by herpes simplex virus type 2 DNA.

Authors:  D D Anthony; W B Wentz; J W Reagan; A D Heggie
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

7.  Maintenance of liver function in long term culture of hepatocytes following in vitro or in vivo Ha-rasEJ transfection.

Authors:  M Fischbach; H W Cao; M Diez Ibanez; C Tsaconas; S Alouani; F Montandon; M el Baraka; P Padieu; M Dreano; M Chessebeuf-Padieu
Journal:  Cell Biol Toxicol       Date:  1991-10       Impact factor: 6.691

Review 8.  Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants.

Authors:  Seleeke Flingai; Matias Czerwonko; Jonathan Goodman; Sagar B Kudchodkar; Kar Muthumani; David B Weiner
Journal:  Front Immunol       Date:  2013-11-04       Impact factor: 7.561

9.  Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation.

Authors:  Ana Paula F Trombone; Célio L Silva; Karla M Lima; Constance Oliver; Maria Célia Jamur; Alan R Prescott; Arlete A M Coelho-Castelo
Journal:  PLoS One       Date:  2007-09-26       Impact factor: 3.240

10.  Bioelectric applications for treatment of melanoma.

Authors:  Stephen J Beebe; Karl H Schoenbach; Richard Heller
Journal:  Cancers (Basel)       Date:  2010-09-27       Impact factor: 6.639
  10 in total

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