Literature DB >> 35401844

LINC00852 Regulates Cell Proliferation, Invasion, Migration and Apoptosis in Hepatocellular Carcinoma Via the miR-625/E2F1 Axis.

Shi Chen1.   

Abstract

Objective: This study investigates the function and regulatory mechanism of lncRNA LINC00852 in hepatocellular carcinoma (HCC) cells.
Methods: The effects of LINC00852 and E2F1 on HCC cell proliferation, invasion, migration and apoptosis were measured by MTT assay, Transwell invasion and migration assays and TUNEL staining, respectively. The apoptosis of HCC cells was further determined by the expression levels of apoptosis-related proteins (Bax and Bcl2). Dual-luciferase reporter assays verified the targeting relationships among LINC00852, miR-625 and E2F1.
Results: Overexpression of LINC00852 was positively associated with HCC cell proliferation, invasion and migration while negatively associated with the cell apoptosis. LINC00852 bound miR-625 which further targeted E2F1. Overexpressing miR-625 or down-regulating E2F1 reversed the oncogenic effects of LINC00852.
Conclusion: LINC00852 regulates HCC cell activities via the miR-625/E2F1 axis. © Biomedical Engineering Society 2021.

Entities:  

Keywords:  E2F1; Hepatocellular carcinoma; Invasion; LINC00852; Migration; Proliferation; miR-625

Year:  2021        PMID： 35401844      PMCID： PMC8938543          DOI： 10.1007/s12195-021-00714-8

Source DB:  PubMed          Journal:  Cell Mol Bioeng        ISSN： 1865-5025            Impact factor:   2.321


  30 in total

1.  miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer.

Authors:  Wen-bin Zhou; Cai-neng Zhong; Xun-peng Luo; Ya-yuan Zhang; Gui-ying Zhang; Dong-xian Zhou; Li-ping Liu
Journal:  Biochem Biophys Res Commun       Date:  2016-01-22       Impact factor: 3.575

2.  miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2.

Authors:  Zhiqiang Wang; Qiao Qiao; Min Chen; Xianhua Li; Zhenjun Wang; Chuanxin Liu; Zongtao Xie
Journal:  FEBS Lett       Date:  2014-02-04       Impact factor: 4.124

Review 3.  E2F1 transcription factor and its impact on growth factor and cytokine signaling.

Authors:  Mustafa Gokhan Ertosun; Fatma Zehra Hapil; Ozes Osman Nidai
Journal:  Cytokine Growth Factor Rev       Date:  2016-03-02       Impact factor: 7.638

Review 4.  Emerging roles of E2Fs in cancer: an exit from cell cycle control.

Authors:  Hui-Zi Chen; Shih-Yin Tsai; Gustavo Leone
Journal:  Nat Rev Cancer       Date:  2009-11       Impact factor: 60.716

5.  MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells.

Authors:  Hailun Zheng; Renqiang Ma; Qizhi Wang; Pei Zhang; Dapeng Li; Qiangwu Wang; Jianchao Wang; Huabin Li; Hao Liu; Zhiwei Wang
Journal:  Oncotarget       Date:  2015-09-29

Review 6.  Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Authors:  Germana Castelli; Elvira Pelosi; Ugo Testa
Journal:  Cancers (Basel)       Date:  2017-09-20       Impact factor: 6.639

7.  The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015.

Authors:  Tomi Akinyemiju; Semaw Abera; Muktar Ahmed; Noore Alam; Mulubirhan Assefa Alemayohu; Christine Allen; Rajaa Al-Raddadi; Nelson Alvis-Guzman; Yaw Amoako; Al Artaman; Tadesse Awoke Ayele; Aleksandra Barac; Isabela Bensenor; Adugnaw Berhane; Zulfiqar Bhutta; Jacqueline Castillo-Rivas; Abdulaal Chitheer; Jee-Young Choi; Benjamin Cowie; Lalit Dandona; Rakhi Dandona; Subhojit Dey; Daniel Dicker; Huyen Phuc; Donatus U. Ekwueme; Maysaa El Sayed Zaki; Florian Fischer; Thomas Fürst; Jamie Hancock; Simon I. Hay; Peter Hotez; Sun Ha Jee; Amir Kasaeian; Yousef Khader; Young-Ho Khang; Anil Kumar; Michael Kutz; Heidi Larson; Alan Lopez; Raimundas Lunevicius; Reza Malekzadeh; Colm McAlinden; Toni Meier; Walter Mendoza; Ali Mokdad; Maziar Moradi-Lakeh; Gabriele Nagel; Quyen Nguyen; Grant Nguyen; Felix Ogbo; George Patton; David M. Pereira; Farshad Pourmalek; Mostafa Qorbani; Amir Radfar; Gholamreza Roshandel; Joshua A Salomon; Juan Sanabria; Benn Sartorius; Maheswar Satpathy; Monika Sawhney; Sadaf Sepanlou; Katya Shackelford; Hirbo Shore; Jiandong Sun; Desalegn Tadese Mengistu; Roman Topór-Mądry; Bach Tran; Vasiliy Vlassov; Stein Emil Vollset; Theo Vos; Tolassa Wakayo; Elisabete Weiderpass; Andrea Werdecker; Naohiro Yonemoto; Mustafa Younis; Chuanhua Yu; Zoubida Zaidi; Liguo Zhu; Christopher J. L. Murray; Mohsen Naghavi; Christina Fitzmaurice
Journal:  JAMA Oncol       Date:  2017-12-01       Impact factor: 31.777

8.  Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells.

Authors:  Blaž Burja; Tadeja Kuret; Tea Janko; Dijana Topalović; Lada Živković; Katjuša Mrak-Poljšak; Biljana Spremo-Potparević; Polona Žigon; Oliver Distler; Saša Čučnik; Snezna Sodin-Semrl; Katja Lakota; Mojca Frank-Bertoncelj
Journal:  Front Cardiovasc Med       Date:  2019-05-16

9.  miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1.

Authors:  Xufei Gong; Baoli Xu; Li Zi; Xinrui Chen
Journal:  Cancer Manag Res       Date:  2019-07-15       Impact factor: 3.989

10.  E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis.

Authors:  Tong-Peng Xu; Yan-Fen Wang; Wei-Liang Xiong; Pei Ma; Wen-Yu Wang; Wen-Ming Chen; Ming-De Huang; Rui Xia; Rong Wang; Er-Bao Zhang; Yan-Wen Liu; Wei De; Yong-Qian Shu
Journal:  Cell Death Dis       Date:  2017-06-01       Impact factor: 8.469
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  1 in total

Review 1.  CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder.

Authors:  Tianlin Jiang; Yanli Wang; Xiaohong Wang; Jun Xu
Journal:  Front Neurosci       Date:  2022-08-18       Impact factor: 5.152
  1 in total

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