Yukimasa Hatachi1,2, Sharad R Mohan3, Takeshi Kotake1,4, Hironaga Satake1,5, Yoshihiro Okita1,6, Hisateru Yasui1, Akihito Tsuji1,6. 1. Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan. 2. Department of Clinical Oncology, Kansai Rosai Hospital, Amagasaki, Japan. 3. Department of Artificial Intelligence, AI Medical and Health Tech Systems, Osaka, Japan. 4. Department of Clinical Oncology, Kansai Electric Power Hospital, Osaka, Japan. 5. Cancer Treatment Center, Kansai Medical University Hospital, Hirakata, Japan. 6. Department of Clinical Oncology, Kagawa University Hospital, Kagawa, Japan.
Abstract
Background/Aim: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, and leucovorin) combination chemotherapy is the gold-standard therapy for advanced pancreatic cancer. In this study, FOLFIRINOX dosages for Japanese patients were established enabling FOLFIRINOX therapy optimization for efficient use. Patients and Methods: Patients with advanced pancreatic cancer were treated with varying doses of FOLFIRINOX to determine the optimum dosage for highest remission outcomes with the least post-chemotherapy toxicities. Results: Patients given 180 mg of irinotecan and a 400 mg bolus of 5-fluorouracil (5-FU) showed a marked difference in outcome when compared to irinotecan 180 mg given without the 5-FU bolus, with the overall response rate being 28%, a survival time of 6.4 months and progression-free survival time of 4.5 months. Conclusion: The optimum dose of FOLFIRINOX was a dosage combination of oxaliplatin 85 mg/m 2 , irinotecan 180 mg/m 2 , l-leucovorin 400 mg/m 2 and 5-FU 2,400 mg/m 2 , administered as a continuous 46-h infusion. Copyright 2022, International Institute of Anticancer Research.
Background/Aim: FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, and leucovorin) combination chemotherapy is the gold-standard therapy for advanced pancreatic cancer. In this study, FOLFIRINOX dosages for Japanese patients were established enabling FOLFIRINOX therapy optimization for efficient use. Patients and Methods: Patients with advanced pancreatic cancer were treated with varying doses of FOLFIRINOX to determine the optimum dosage for highest remission outcomes with the least post-chemotherapy toxicities. Results: Patients given 180 mg of irinotecan and a 400 mg bolus of 5-fluorouracil (5-FU) showed a marked difference in outcome when compared to irinotecan 180 mg given without the 5-FU bolus, with the overall response rate being 28%, a survival time of 6.4 months and progression-free survival time of 4.5 months. Conclusion: The optimum dose of FOLFIRINOX was a dosage combination of oxaliplatin 85 mg/m 2 , irinotecan 180 mg/m 2 , l-leucovorin 400 mg/m 2 and 5-FU 2,400 mg/m 2 , administered as a continuous 46-h infusion. Copyright 2022, International Institute of Anticancer Research.
Entities:
Keywords:
FOLFIRINOX; dose limiting toxicity; optimal dose; pancreatic cancer
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