Yuichi Hiroshima1,2,3, Yoshio Tamaki1,2, Takuya Sawada1,2, Motohiro Murakami2, Toshiki Ishida1,2, Takashi Saitoh2, Hiroshi Kojima4,5, Toshiyuki Okumura2, Hideyuki Sakurai2. 1. Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan. 2. Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan. 3. QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. 4. Ibaraki Clinical Education and Training Center, University of Tsukuba Hospital, Kasama, Japan. 5. Department of Medical Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.
Abstract
Background: Langerhans cell histiocytosis (LCH) is a rare disease, especially in adults. It is often associated with non-fatal bone and skin lesions and has relatively good radiosensitivity. In contrast, brain and lymph node metastases from LCH lesions are considered to be less sensitive to radiotherapy. Case Report: At our institution, 30 Gy radiotherapy was used to treat bone lesions with dural invasion in a patient with adult-onset LCH. The patient was treated with chemotherapy and radiotherapy for 21 years since the initial diagnosis. After radiotherapy, the tumor shrank rapidly, and a complete response was achieved 1 year after treatment. The patient survived without local recurrence. Conclusion: Here, we report the details of this case, along with a review of the literature. We suggest that even with invasion of the tissues around the bone lesions in LCH, local recurrence can be prevented by middle radiation doses. Copyright 2022, International Institute of Anticancer Research.
Background: Langerhans cell histiocytosis (LCH) is a rare disease, especially in adults. It is often associated with non-fatal bone and skin lesions and has relatively good radiosensitivity. In contrast, brain and lymph node metastases from LCH lesions are considered to be less sensitive to radiotherapy. Case Report: At our institution, 30 Gy radiotherapy was used to treat bone lesions with dural invasion in a patient with adult-onset LCH. The patient was treated with chemotherapy and radiotherapy for 21 years since the initial diagnosis. After radiotherapy, the tumor shrank rapidly, and a complete response was achieved 1 year after treatment. The patient survived without local recurrence. Conclusion: Here, we report the details of this case, along with a review of the literature. We suggest that even with invasion of the tissues around the bone lesions in LCH, local recurrence can be prevented by middle radiation doses. Copyright 2022, International Institute of Anticancer Research.
Entities:
Keywords:
Langerhans cell histiocytosis; adult onset; bone metastasis; local control; radiotherapy; skull
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