Literature DB >> 35398879

Oncogene Convergence in Extrachromosomal DNA Hubs.

Natasha E Weiser1,2, King L Hung1, Howard Y Chang1,3.   

Abstract

Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution. ©2022 The Authors; Published by the American Association for Cancer Research.

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Year:  2022        PMID： 35398879      PMCID： PMC9302380          DOI： 10.1158/2159-8290.CD-22-0076

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   38.272


  18 in total

1.  MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD.

Authors:  D COX; C YUNCKEN; A I SPRIGGS
Journal:  Lancet       Date:  1965-07-10       Impact factor: 79.321

2.  Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.

Authors:  Andrew R Morton; Nergiz Dogan-Artun; Zachary J Faber; Graham MacLeod; Cynthia F Bartels; Megan S Piazza; Kevin C Allan; Stephen C Mack; Xiuxing Wang; Ryan C Gimple; Qiulian Wu; Brian P Rubin; Shashirekha Shetty; Stephane Angers; Peter B Dirks; Richard C Sallari; Mathieu Lupien; Jeremy N Rich; Peter C Scacheri
Journal:  Cell       Date:  2019-11-21       Impact factor: 41.582

3.  Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation.

Authors:  Yoshihiro Oobatake; Noriaki Shimizu
Journal:  Genes Chromosomes Cancer       Date:  2019-10-04       Impact factor: 5.006

4.  HiChIP: efficient and sensitive analysis of protein-directed genome architecture.

Authors:  Maxwell R Mumbach; Adam J Rubin; Ryan A Flynn; Chao Dai; Paul A Khavari; William J Greenleaf; Howard Y Chang
Journal:  Nat Methods       Date:  2016-09-19       Impact factor: 28.547

Review 5.  Extrachromosomal DNA: An Emerging Hallmark in Human Cancer.

Authors:  Sihan Wu; Vineet Bafna; Howard Y Chang; Paul S Mischel
Journal:  Annu Rev Pathol       Date:  2021-11-09       Impact factor: 32.350

6.  ecDNA hubs drive cooperative intermolecular oncogene expression.

Authors:  King L Hung; Kathryn E Yost; Liangqi Xie; Quanming Shi; Konstantin Helmsauer; Jens Luebeck; Robert Schöpflin; Joshua T Lange; Rocío Chamorro González; Natasha E Weiser; Celine Chen; Maria E Valieva; Ivy Tsz-Lo Wong; Sihan Wu; Siavash R Dehkordi; Connor V Duffy; Katerina Kraft; Jun Tang; Julia A Belk; John C Rose; M Ryan Corces; Jeffrey M Granja; Rui Li; Utkrisht Rajkumar; Jordan Friedlein; Anindya Bagchi; Ansuman T Satpathy; Robert Tjian; Stefan Mundlos; Vineet Bafna; Anton G Henssen; Paul S Mischel; Zhe Liu; Howard Y Chang
Journal:  Nature       Date:  2021-11-24       Impact factor: 69.504

7.  Nonselective DNA damage induced by a replication inhibitor results in the selective elimination of extrachromosomal double minutes from human cancer cells.

Authors:  Noriaki Shimizu; Naomi Misaka; Koh-ichi Utani
Journal:  Genes Chromosomes Cancer       Date:  2007-10       Impact factor: 5.006

8.  Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription.

Authors:  Yanfen Zhu; Amit D Gujar; Chee-Hong Wong; Harianto Tjong; Chew Yee Ngan; Liang Gong; Yi-An Chen; Hoon Kim; Jihe Liu; Meihong Li; Adam Mil-Homens; Rahul Maurya; Chris Kuhlberg; Fanyue Sun; Eunhee Yi; Ana C deCarvalho; Yijun Ruan; Roel G W Verhaak; Chia-Lin Wei
Journal:  Cancer Cell       Date:  2021-04-08       Impact factor: 31.743

9.  Chromothripsis drives the evolution of gene amplification in cancer.

Authors:  Ofer Shoshani; Simon F Brunner; Rona Yaeger; Peter Ly; Yael Nechemia-Arbely; Dong Hyun Kim; Rongxin Fang; Guillaume A Castillon; Miao Yu; Julia S Z Li; Ying Sun; Mark H Ellisman; Bing Ren; Peter J Campbell; Don W Cleveland
Journal:  Nature       Date:  2020-12-23       Impact factor: 49.962

10.  Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.

Authors:  Hoon Kim; Nam-Phuong Nguyen; Kristen Turner; Sihan Wu; Amit D Gujar; Jens Luebeck; Jihe Liu; Viraj Deshpande; Utkrisht Rajkumar; Sandeep Namburi; Samirkumar B Amin; Eunhee Yi; Francesca Menghi; Johannes H Schulte; Anton G Henssen; Howard Y Chang; Christine R Beck; Paul S Mischel; Vineet Bafna; Roel G W Verhaak
Journal:  Nat Genet       Date:  2020-08-17       Impact factor: 41.307
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  1 in total

1.  Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints.

Authors:  Philip D Tatman; Joshua C Black
Journal:  Cancers (Basel)       Date:  2022-05-06       Impact factor: 6.575
  1 in total

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