| Literature DB >> 3539884 |
W C Cole, S J DeNardo, C F Meares, M J McCall, G L DeNardo, A L Epstein, H A O'Brien, M K Moi.
Abstract
Simple chelates and chelate conjugated monoclonal antibodies labeled with 111In, 57Co and 67Cu demonstrate marked differences in stability when exposed to a serum environment. Among these radiometals, on DTPA, the order of stability is 111In greater than 57Co much greater than 67Cu. On benzyl-EDTA, the order of stability is 111In congruent to 57Co much greater than 67Cu. Among those investigated, the only serum stable 67Cu chelate found was 67Cu-TETA. The order of stability observed for 57Co vs 67Cu is contrary to published equilibrium constants. These in vitro studies suggest that the in vivo behavior of metal chelates exposed to a complex molecular environment may not be predicted by classically determined equilibrium constants.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3539884 DOI： 10.1016/0883-2897(86)90011-5
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897