| Literature DB >> 35397211 |
Joseph M Stujenske1, Pia-Kelsey O'Neill2, Carolina Fernandes-Henriques3, Itzick Nahmoud4, Samantha R Goldburg5, Ashna Singh6, Laritza Diaz7, Margarita Labkovich8, William Hardin9, Scott S Bolkan10, Thomas R Reardon11, Timothy J Spellman12, C Daniel Salzman13, Joshua A Gordon14, Conor Liston6, Ekaterina Likhtik15.
Abstract
The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli.Entities:
Keywords: amygdala; discrimination; interneurons; non-threat; oscillations; prelimbic; safety; somatostatin
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Year: 2022 PMID： 35397211 PMCID： PMC9308671 DOI： 10.1016/j.neuron.2022.03.020
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 18.688