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Literature DB >> 35396481

Human organoid models to study SARS-CoV-2 infection.

Yuling Han¹, Liuliu Yang¹, Lauretta A Lacko¹, Shuibing Chen².

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS-CoV-2 not only infects the respiratory tract, but also causes damage to many organs. Organoids, which can self-renew and recapitulate the various physiology of different organs, serve as powerful platforms to model COVID-19. In this Perspective, we overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development. We summarize the technologies used in organoid-based COVID-19 research, discuss the remaining challenges and provide future perspectives in the application of organoid models to study SARS-CoV-2 and future emerging viruses.

Entities: Chemical

Mesh：

Year: 2022 PMID： 35396481 DOI： 10.1038/s41592-022-01453-y

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

106 in total

1. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

Authors: Mototsugu Eiraku; Kiichi Watanabe; Mami Matsuo-Takasaki; Masako Kawada; Shigenobu Yonemura; Michiru Matsumura; Takafumi Wataya; Ayaka Nishiyama; Keiko Muguruma; Yoshiki Sasai
Journal: Cell Stem Cell Date: 2008-11-06 Impact factor: 24.633

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Authors: H V Wilson
Journal: Science Date: 1907-06-07 Impact factor: 47.728

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Journal: In Vitro Date: 1977-05

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Journal: J Reprod Fertil Date: 1981-07

5. Establishment in culture of pluripotential cells from mouse embryos.

Authors: M J Evans; M H Kaufman
Journal: Nature Date: 1981-07-09 Impact factor: 49.962

6. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

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Authors: G R Martin
Journal: Proc Natl Acad Sci U S A Date: 1981-12 Impact factor: 11.205

8. Embryonic stem cell lines derived from human blastocysts.

Authors: J A Thomson; J Itskovitz-Eldor; S S Shapiro; M A Waknitz; J J Swiergiel; V S Marshall; J M Jones
Journal: Science Date: 1998-11-06 Impact factor: 47.728

9. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.

Authors: J G Rheinwald; H Green
Journal: Cell Date: 1975-11 Impact factor: 41.582

Review 6. Three-Dimensional In Vitro Cell Culture Models for Efficient Drug Discovery: Progress So Far and Future Prospects.

Authors: Shaimaa M Badr-Eldin; Hibah M Aldawsari; Sabna Kotta; Pran Kishore Deb; Katharigatta N Venugopala
Journal: Pharmaceuticals (Basel) Date: 2022-07-27

6 in total

Human organoid models to study SARS-CoV-2 infection.

1. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

2. A NEW METHOD BY WHICH SPONGES MAY BE ARTIFICIALLY REARED.

3. Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes.

Review 4. Origin of mouse embryonal carcinoma cells and the possibility of their direct isolation into tissue culture.

5. Establishment in culture of pluripotential cells from mouse embryos.

6. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

7. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

8. Embryonic stem cell lines derived from human blastocysts.

9. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.

Review 10. Modeling Development and Disease with Organoids.

Review 1. 3D Human Organoids: The Next "Viral" Model for the Molecular Basis of Infectious Diseases.

Review 2. Lung Organoids as Model to Study SARS-CoV-2 Infection.

3. Better In Vitro Tools for Exploring Chlamydia trachomatis Pathogenesis.

Review 4. 3D Lung Tissue Models for Studies on SARS-CoV-2 Pathophysiology and Therapeutics.

Review 5. Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review.

Review 6. Three-Dimensional In Vitro Cell Culture Models for Efficient Drug Discovery: Progress So Far and Future Prospects.