Literature DB >> 35394495

Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage.

Marco De Dominici, James DeGregori1.   

Abstract

SUMMARY: Dnmt3a-mutant stem cells gain a competitive advantage via upregulation of a Txnip-p53-p21 axis and protection from IFNγ induced exhaustion. See related article by Zhang et al., p. 220 (5). ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35394495      PMCID： PMC9245326          DOI： 10.1158/2643-3230.BCD-22-0025

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  10 in total

1.  Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.

Authors:  Christine R C Zhang; Darren Nix; Martin Gregory; Matthew A Ciorba; Elizabeth L Ostrander; Rodney D Newberry; David H Spencer; Grant A Challen
Journal:  Exp Hematol       Date:  2019-12-05       Impact factor: 3.084

2.  TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress.

Authors:  Haiyoung Jung; Mi Jeong Kim; Dong Oh Kim; Won Sam Kim; Sung-Jin Yoon; Young-Jun Park; Suk Ran Yoon; Tae-Don Kim; Hyun-Woo Suh; Sohyun Yun; Jeong-Ki Min; Hee Gu Lee; Young Ho Lee; Hee-Jun Na; Dong Chul Lee; Hyoung-Chin Kim; Inpyo Choi
Journal:  Cell Metab       Date:  2013-07-02       Impact factor: 27.287

3.  Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response.

Authors:  Marina Scheller; Anne Kathrin Ludwig; Stefanie Göllner; Christian Rohde; Stephen Krämer; Sina Stäble; Maike Janssen; James-Arne Müller; Lixiazi He; Nicole Bäumer; Christian Arnold; Joachim Gerß; Maximilian Schönung; Christian Thiede; Christian Niederwieser; Dietger Niederwieser; Hubert Serve; Wolfgang E Berdel; Ulrich Thiem; Inga Hemmerling; Florian Leuschner; Christoph Plass; Matthias Schlesner; Judith Zaugg; Michael D Milsom; Andreas Trumpp; Caroline Pabst; Daniel B Lipka; Carsten Müller-Tidow
Journal:  Nat Cancer       Date:  2021-05-25

4.  Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21.

Authors:  Christine R Zhang; Elizabeth L Ostrander; Ostap Kukhar; Cates Mallaney; Jiameng Sun; Emily Haussler; Hamza Celik; Won Kyun Koh; Katherine Y King; Paul Gontarz; Grant A Challen
Journal:  Blood Cancer Discov       Date:  2022-05-05

Review 5.  Clonal hematopoiesis in human aging and disease.

Authors:  Siddhartha Jaiswal; Benjamin L Ebert
Journal:  Science       Date:  2019-11-01       Impact factor: 47.728

Review 6.  Yin and Yang: The dual effects of interferons on hematopoiesis.

Authors:  Yasmin Demerdash; Bailee Kain; Marieke A G Essers; Katherine Y King
Journal:  Exp Hematol       Date:  2021-02-08       Impact factor: 3.084

7.  Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.

Authors:  Daniel Hormaechea-Agulla; Katie A Matatall; Duy T Le; Bailee Kain; Xiaochen Long; Pawel Kus; Roman Jaksik; Grant A Challen; Marek Kimmel; Katherine Y King
Journal:  Cell Stem Cell       Date:  2021-03-19       Impact factor: 25.269

8.  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.

Authors:  Haiyoung Jung; Dong Oh Kim; Jae-Eun Byun; Won Sam Kim; Mi Jeong Kim; Hae Young Song; Young Kwan Kim; Du-Kyeong Kang; Young-Jun Park; Tae-Don Kim; Suk Ran Yoon; Hee Gu Lee; Eun-Ji Choi; Sang-Hyun Min; Inpyo Choi
Journal:  Nat Commun       Date:  2016-12-08       Impact factor: 14.919

9.  Prediction of acute myeloid leukaemia risk in healthy individuals.

Authors:  Sagi Abelson; Grace Collord; Stanley W K Ng; Omer Weissbrod; Netta Mendelson Cohen; Elisabeth Niemeyer; Noam Barda; Philip C Zuzarte; Lawrence Heisler; Yogi Sundaravadanam; Robert Luben; Shabina Hayat; Ting Ting Wang; Zhen Zhao; Iulia Cirlan; Trevor J Pugh; David Soave; Karen Ng; Calli Latimer; Claire Hardy; Keiran Raine; David Jones; Diana Hoult; Abigail Britten; John D McPherson; Mattias Johansson; Faridah Mbabaali; Jenna Eagles; Jessica K Miller; Danielle Pasternack; Lee Timms; Paul Krzyzanowski; Philip Awadalla; Rui Costa; Eran Segal; Scott V Bratman; Philip Beer; Sam Behjati; Inigo Martincorena; Jean C Y Wang; Kristian M Bowles; J Ramón Quirós; Anna Karakatsani; Carlo La Vecchia; Antonia Trichopoulou; Elena Salamanca-Fernández; José M Huerta; Aurelio Barricarte; Ruth C Travis; Rosario Tumino; Giovanna Masala; Heiner Boeing; Salvatore Panico; Rudolf Kaaks; Alwin Krämer; Sabina Sieri; Elio Riboli; Paolo Vineis; Matthieu Foll; James McKay; Silvia Polidoro; Núria Sala; Kay-Tee Khaw; Roel Vermeulen; Peter J Campbell; Elli Papaemmanuil; Mark D Minden; Amos Tanay; Ran D Balicer; Nicholas J Wareham; Moritz Gerstung; John E Dick; Paul Brennan; George S Vassiliou; Liran I Shlush
Journal:  Nature       Date:  2018-07-09       Impact factor: 49.962

10.  Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

Authors:  Ryan N Ptashkin; Teng Gao; Ahmet Zehir; Elli Papaemmanuil; Kelly L Bolton; Lior Braunstein; Sean M Devlin; Daniel Kelly; Minal Patel; Antonin Berthon; Aijazuddin Syed; Mariko Yabe; Catherine C Coombs; Nicole M Caltabellotta; Mike Walsh; Kenneth Offit; Zsofia Stadler; Diana Mandelker; Jessica Schulman; Akshar Patel; John Philip; Elsa Bernard; Gunes Gundem; Juan E Arango Ossa; Max Levine; Juan S Medina Martinez; Noushin Farnoud; Dominik Glodzik; Sonya Li; Mark E Robson; Choonsik Lee; Paul D P Pharoah; Konrad H Stopsack; Barbara Spitzer; Simon Mantha; James Fagin; Laura Boucai; Christopher J Gibson; Benjamin L Ebert; Andrew L Young; Todd Druley; Koichi Takahashi; Nancy Gillis; Markus Ball; Eric Padron; David M Hyman; Jose Baselga; Larry Norton; Stuart Gardos; Virginia M Klimek; Howard Scher; Dean Bajorin; Eder Paraiso; Ryma Benayed; Maria E Arcila; Marc Ladanyi; David B Solit; Michael F Berger; Martin Tallman; Montserrat Garcia-Closas; Nilanjan Chatterjee; Luis A Diaz; Ross L Levine; Lindsay M Morton
Journal:  Nat Genet       Date:  2020-10-26       Impact factor: 41.307
  10 in total

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