| Literature DB >> 3539055 |
M R Dzoljic, B Rademaker, A L vd Poel-Heisterkamp, O E Ukponmwan, J Haffmans.
Abstract
The effect of the enkephalinase inhibitor phosphoramidon on the withdrawal syndrome following acute and chronic morphine-induced physical dependence in mice, was investigated. Phosphoramidon administered intracerebroventricularly (50-200 micrograms) suppressed significantly the naloxone-precipitated withdrawal jumping and wet dog shakes while forelimb shakes were potentiated in both acute and chronic morphine-dependent mice. It is suggested that increased saturation of the opioid receptors by endogenous opioid peptides following enkephalinase inhibition, might suppress the severity of the withdrawal syndrome.Entities:
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Year: 1986 PMID： 3539055
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780