Beatriz F Leite1, Melissa A Morimoto2, Carina M F Gomes2, Barbara N C Klemz2, Patrícia S Genaro3, Nittin Shivappa4, James R Hébert4, Nágila R T Damasceno5, Marcelo M Pinheiro2. 1. Rheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil. leitebf@gmail.com. 2. Rheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil. 3. Department of Nutrition, Vale Do Paraíba University, 2911 Shishima Hifumi Av, Urbanova, Sao Jose dos Campos, São Paulo, 12244-000, Brazil. 4. Cancer Prevention and Control Program and Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA. 5. Nutrition Department, Public Health School, Sao Paulo University, 715 Dr Arnaldo Av, Pacaembu, São Paulo, SP, 01246-904, Brazil.
Abstract
AIM: To evaluate whether dietary pattern changes, antioxidant supplementation or 5-10% weight loss could improve disease activity (skin and joint) in patients with psoriatic arthritis (PsA). METHODS: A total of 97 PsA patients were enrolled in this 12-week randomized, double-blinded, placebo-controlled trial. Patients were randomized into three groups: Diet-placebo (hypocaloric diet + placebo supplementation); Diet-fish (hypocaloric diet + 3 g/day of omega-3 supplementation; and Placebo. Food intake (3-day registry, Healthy Eating Index (HEI), and the Dietary Inflammatory Index (DII)), body composition (whole-body dual-energy X-ray absorptiometry (DXA), weight and waist circumference) and disease activity (PASI, BSA, BASDAI, DAS28-ESR, DAS28-CRP and MDA) were evaluated at baseline and after the 12-week intervention. Statistical analysis used the intention-to-treat approach. The P value was considered to indicate significance when below 0.05. RESULTS: After 12 weeks, DAS28-CRP and BASDAI scores improved, especially in the Diet-placebo group (- 0.6 ± 0.9; p = 0.004 and - 1.39 ± 1.97; p = 0.001, respectively). In addition, a higher proportion of patients achieved minimal disease activity (MDA) in all groups. The Diet-fish group showed significant weight loss (- 1.79 ± 2.4; p = 0.004), as well as waist circumference (- 3.28 ± 3.5, p < 0.001) and body fat (- 1.2 ± 2.2, p = 0.006) reductions. There was no significant correlation between weight loss and disease activity improvement. Each 1-unit increase in the HEI value reduced the likelihood of achieving remission by 4%. Additionally, each 100-cal daily intake increase caused a 3.4-fold DAS28-ESR impairment. CONCLUSION: A 12-week hypocaloric intervention provided suitable control of joint disease activity in patients with PsA, regardless of weight loss. Adding omega-3 supplementation caused relevant body composition changes but not disease activity improvement. TRIAL REGISTRATION: The study was recorded on Clinicaltrials.gov (NCT03142503).
AIM: To evaluate whether dietary pattern changes, antioxidant supplementation or 5-10% weight loss could improve disease activity (skin and joint) in patients with psoriatic arthritis (PsA). METHODS: A total of 97 PsA patients were enrolled in this 12-week randomized, double-blinded, placebo-controlled trial. Patients were randomized into three groups: Diet-placebo (hypocaloric diet + placebo supplementation); Diet-fish (hypocaloric diet + 3 g/day of omega-3 supplementation; and Placebo. Food intake (3-day registry, Healthy Eating Index (HEI), and the Dietary Inflammatory Index (DII)), body composition (whole-body dual-energy X-ray absorptiometry (DXA), weight and waist circumference) and disease activity (PASI, BSA, BASDAI, DAS28-ESR, DAS28-CRP and MDA) were evaluated at baseline and after the 12-week intervention. Statistical analysis used the intention-to-treat approach. The P value was considered to indicate significance when below 0.05. RESULTS: After 12 weeks, DAS28-CRP and BASDAI scores improved, especially in the Diet-placebo group (- 0.6 ± 0.9; p = 0.004 and - 1.39 ± 1.97; p = 0.001, respectively). In addition, a higher proportion of patients achieved minimal disease activity (MDA) in all groups. The Diet-fish group showed significant weight loss (- 1.79 ± 2.4; p = 0.004), as well as waist circumference (- 3.28 ± 3.5, p < 0.001) and body fat (- 1.2 ± 2.2, p = 0.006) reductions. There was no significant correlation between weight loss and disease activity improvement. Each 1-unit increase in the HEI value reduced the likelihood of achieving remission by 4%. Additionally, each 100-cal daily intake increase caused a 3.4-fold DAS28-ESR impairment. CONCLUSION: A 12-week hypocaloric intervention provided suitable control of joint disease activity in patients with PsA, regardless of weight loss. Adding omega-3 supplementation caused relevant body composition changes but not disease activity improvement. TRIAL REGISTRATION: The study was recorded on Clinicaltrials.gov (NCT03142503).
Authors: Willemijn A van Gemert; Anne M May; Albertine J Schuit; Blanche Y M Oosterhof; Petra H Peeters; Evelyn M Monninkhof Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-02-16 Impact factor: 4.254
Authors: Batya B Davidovici; Naveed Sattar; Jörg C Prinz; Prinz C Jörg; Luis Puig; Paul Emery; Jonathan N Barker; Peter van de Kerkhof; Mona Ståhle; Frank O Nestle; Giampiero Girolomoni; James G Krueger Journal: J Invest Dermatol Date: 2010-05-06 Impact factor: 8.551
Authors: Anna Polus; Barbara Zapala; Urszula Razny; Anna Gielicz; Beata Kiec-Wilk; Malgorzata Malczewska-Malec; Marek Sanak; Caroline E Childs; Philip C Calder; Aldona Dembinska-Kiec Journal: Biochim Biophys Acta Date: 2016-08-12