PURPOSE: While inpatient rehabilitation can improve functional independence in patients with cancer, the role of cachexia in this population is unknown. Our objectives were to: 1) Establish prevalence of cachexia in a cohort of cancer patients receiving inpatient rehabilitation and its association with demographic and oncological history. 2) Determine the relationship between the presence of cachexia and functional recovery and whether these patients in inpatient rehabilitation have a distinct prognosis. METHODS: Retrospective cohort study of 250 patients over 330 admissions to an Inpatient Rehabilitation Facility. Body weight loss (BWL) threshold and Weight Loss Grading Scale (WLGS) indentified patients with and without cachexia. Main Outcomes were Functional independence Measure (FIM) scores, discharge destination, and 6-month survival. RESULTS: Prevalence of cachexia in inpatient rehabilitation was 59% using consensus BWL criteria and 77% of cancer patients had WLGS>0. Patients with and without cachexia had similar motor and cognitive gains though patients with severe cachexia had more limited functional gains(p < 0.05) and increased odds of acute care return(p < 0.01). Patients with WLGS = 4 had decreased survival at six months(p < 0.05) compared to non-cachectic patients. CONCLUSIONS: These data suggest that there is a relationship between cachexia and recovery for cancer patients that should be further studied in rehabilitation settings.
PURPOSE: While inpatient rehabilitation can improve functional independence in patients with cancer, the role of cachexia in this population is unknown. Our objectives were to: 1) Establish prevalence of cachexia in a cohort of cancer patients receiving inpatient rehabilitation and its association with demographic and oncological history. 2) Determine the relationship between the presence of cachexia and functional recovery and whether these patients in inpatient rehabilitation have a distinct prognosis. METHODS: Retrospective cohort study of 250 patients over 330 admissions to an Inpatient Rehabilitation Facility. Body weight loss (BWL) threshold and Weight Loss Grading Scale (WLGS) indentified patients with and without cachexia. Main Outcomes were Functional independence Measure (FIM) scores, discharge destination, and 6-month survival. RESULTS: Prevalence of cachexia in inpatient rehabilitation was 59% using consensus BWL criteria and 77% of cancer patients had WLGS>0. Patients with and without cachexia had similar motor and cognitive gains though patients with severe cachexia had more limited functional gains(p < 0.05) and increased odds of acute care return(p < 0.01). Patients with WLGS = 4 had decreased survival at six months(p < 0.05) compared to non-cachectic patients. CONCLUSIONS: These data suggest that there is a relationship between cachexia and recovery for cancer patients that should be further studied in rehabilitation settings.
Authors: Monica P Parmar; Brandy L Vanderbyl; Mary Kanbalian; Tamara Y Windholz; Anh-Thi Tran; R Thomas Jagoe Journal: BMJ Support Palliat Care Date: 2017-08-28 Impact factor: 3.568
Authors: W D Dewys; C Begg; P T Lavin; P R Band; J M Bennett; J R Bertino; M H Cohen; H O Douglass; P F Engstrom; E Z Ezdinli; J Horton; G J Johnson; C G Moertel; M M Oken; C Perlia; C Rosenbaum; M N Silverstein; R T Skeel; R W Sponzo; D C Tormey Journal: Am J Med Date: 1980-10 Impact factor: 4.965
Authors: Vickie E Baracos; Lisa Martin; Murray Korc; Denis C Guttridge; Kenneth C H Fearon Journal: Nat Rev Dis Primers Date: 2018-01-18 Impact factor: 52.329
Authors: Alpa V Patel; Christine M Friedenreich; Steven C Moore; Sandra C Hayes; Julie K Silver; Kristin L Campbell; Kerri Winters-Stone; Lynn H Gerber; Stephanie M George; Janet E Fulton; Crystal Denlinger; G Stephen Morris; Trisha Hue; Kathryn H Schmitz; Charles E Matthews Journal: Med Sci Sports Exerc Date: 2019-11 Impact factor: 5.411
Authors: An Ngo-Huang; Aliea Herbert; Rhodora C Fontillas; Nathan H Parker; Roan Asumbrado; Naveen Garg; Seyedeh Dibaj; Diane D Liu; Amy H Ng; Ying Guo; Ki Y Shin; Matthew H G Katz; Eduardo Bruera Journal: Integr Cancer Ther Date: 2021 Jan-Dec Impact factor: 3.279