| Literature DB >> 35383335 |
Barbara Franke1,2,3, Paul M Thompson4, Hilleke E Hulshoff Pol5,6, Rachel M Brouwer7,8, Marieke Klein9,10,1,2, Katrina L Grasby11, Hugo G Schnack9,12, Neda Jahanshad4, Jalmar Teeuw9, Sophia I Thomopoulos4, Emma Sprooten13, Carol E Franz14, Nitin Gogtay15, William S Kremen14,16, Matthew S Panizzon14, Loes M Olde Loohuis17, Christopher D Whelan18, Moji Aghajani19,20, Clara Alloza21, Dag Alnæs22,23, Eric Artiges24, Rosa Ayesa-Arriola25,26,27, Gareth J Barker28, Mark E Bastin29,30,31, Elisabet Blok32, Erlend Bøen33, Isabella A Breukelaar34, Joanna K Bright4, Elizabeth E L Buimer9, Robin Bülow35, Dara M Cannon36, Simone Ciufolini37, Nicolas A Crossley37,38, Christienne G Damatac13, Paola Dazzan39, Casper L de Mol40, Sonja M C de Zwarte9, Sylvane Desrivières41, Covadonga M Díaz-Caneja21, Nhat Trung Doan22, Katharina Dohm42, Juliane H Fröhner43, Janik Goltermann42, Antoine Grigis44, Dominik Grotegerd42, Laura K M Han19, Mathew A Harris29, Catharina A Hartman45, Sarah J Heany46, Walter Heindel47, Dirk J Heslenfeld48, Sarah Hohmann49, Bernd Ittermann50, Philip R Jansen51,32,52, Joost Janssen21, Tianye Jia53,54, Jiyang Jiang55, Christiane Jockwitz56,57, Temmuz Karali58,59, Daniel Keeser58,59,60, Martijn G J C Koevoets9, Rhoshel K Lenroot61,62,63, Berend Malchow64, René C W Mandl9, Vicente Medel38, Susanne Meinert42,65, Catherine A Morgan66,67, Thomas W Mühleisen56,68,69, Leila Nabulsi36, Nils Opel42,70, Víctor Ortiz-García de la Foz25,26,71, Bronwyn J Overs63, Marie-Laure Paillère Martinot24,72, Ronny Redlich42,73, Tiago Reis Marques37,74, Jonathan Repple42, Gloria Roberts61, Gennady V Roshchupkin75,76, Nikita Setiaman9,32, Elena Shumskaya1,13, Frederike Stein77, Gustavo Sudre78, Shun Takahashi58,79, Anbupalam Thalamuthu55, Diana Tordesillas-Gutiérrez80,81, Aad van der Lugt76, Neeltje E M van Haren9,32, Joanna M Wardlaw29,82, Wei Wen55, Henk-Jan Westeneng83, Katharina Wittfeld84,85, Alyssa H Zhu4, Andre Zugman86,87, Nicola J Armstrong88, Gaia Bonfiglio51, Janita Bralten1,2, Shareefa Dalvie46, Gail Davies29,89, Marta Di Forti41, Linda Ding4, Gary Donohoe90, Andreas J Forstner56,91,92, Javier Gonzalez-Peñas21, Joao P O F T Guimaraes1,13, Georg Homuth93, Jouke-Jan Hottenga94, Maria J Knol75, John B J Kwok95,96, Stephanie Le Hellard97,98, Karen A Mather55,63, Yuri Milaneschi19, Derek W Morris90, Markus M Nöthen92, Sergi Papiol26,58,99, Marcella Rietschel100, Marcos L Santoro86,87,101, Vidar M Steen97,98, Jason L Stein102, Fabian Streit100, Rick M Tankard88, Alexander Teumer103, Dennis van 't Ent94, Dennis van der Meer22,23,104, Kristel R van Eijk83, Evangelos Vassos41,105, Javier Vázquez-Bourgon25,26,27, Stephanie H Witt100, Hieab H H Adams76,106,107, Ingrid Agartz22,108,109, David Ames110,111, Katrin Amunts56,68, Ole A Andreassen22,23, Celso Arango21, Tobias Banaschewski49, Bernhard T Baune112,113,114, Sintia I Belangero86,87,101, Arun L W Bokde115, Dorret I Boomsma94, Rodrigo A Bressan86,87,116, Henry Brodaty55, Jan K Buitelaar13,117, Wiepke Cahn9,118, Svenja Caspers56,57, Sven Cichon56,69,119, Benedicto Crespo-Facorro26,120, Simon R Cox29,121, Udo Dannlowski42, Torbjørn Elvsåshagen122,123,124, Thomas Espeseth125,126, Peter G Falkai58, Simon E Fisher2,127, Herta Flor128, Janice M Fullerton63,96, Hugh Garavan129, Penny A Gowland130, Hans J Grabe84,85, Tim Hahn42, Andreas Heinz131, Manon Hillegers9,32, Jacqueline Hoare46,132, Pieter J Hoekstra133, Mohammad A Ikram75, Andrea P Jackowski86,87, Andreas Jansen77,134, Erik G Jönsson22,108, Rene S Kahn135,136, Tilo Kircher77, Mayuresh S Korgaonkar34,95, Axel Krug77,137, Herve Lemaitre138, Ulrik F Malt139, Jean-Luc Martinot24, Colm McDonald36, Philip B Mitchell61, Ryan L Muetzel32, Robin M Murray37, Frauke Nees49,128,140, Igor Nenadić77, Jaap Oosterlaan141,142, Roel A Ophoff17,143, Pedro M Pan86,87, Brenda W J H Penninx19, Luise Poustka144, Perminder S Sachdev55,145, Giovanni A Salum87,146,147, Peter R Schofield63,96, Gunter Schumann148,149, Philip Shaw78,150, Kang Sim151,152, Michael N Smolka153, Dan J Stein154, Julian N Trollor55,155, Leonard H van den Berg83, Jan H Veldink83, Henrik Walter156, Lars T Westlye22,23,125, Robert Whelan157, Tonya White32,76, Margaret J Wright158,159, Sarah E Medland160.
Abstract
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.Entities:
Mesh：
Year: 2022 PMID： 35383335 DOI： 10.1038/s41593-022-01042-4
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 28.771