Literature DB >> 35380712

The Essentials of Multiomics.

John L Marshall1, Beth N Peshkin2, Takayuki Yoshino3, Jakob Vowinckel4, Håvard E Danielsen5, Gerry Melino6, Ioannis Tsamardinos7, Christian Haudenschild8, David J Kerr9, Carlos Sampaio10, Sun Young Rha11, Kevin T FitzGerald12, Eric C Holland13, David Gallagher14, Jesus Garcia-Foncillas15, Hartmut Juhl16.   

Abstract

Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, transcriptomics, proteomics, circulating omics, and artificial intelligence are now commonplace, and this rapid evolution has left us with a significant knowledge gap within the medical community. In this paper, we attempt to bridge that gap and prepare the physician in oncology for multiomics, a group of technologies that have gone from looming on the horizon to become a clinical reality. The era of multiomics is here, and we must prepare ourselves for this exciting new age of cancer medicine.
© The Author(s) 2022. Published by Oxford University Press.

Entities:  

Keywords:  artificial intelligence; cancer; digital pathology; genomics; machine learning; multiomics; proteomics; transcriptomics

Mesh:

Year:  2022        PMID: 35380712      PMCID: PMC8982374          DOI: 10.1093/oncolo/oyab048

Source DB:  PubMed          Journal:  Oncologist        ISSN: 1083-7159


  63 in total

1.  Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision.

Authors:  Annika Spruessel; Garnet Steimann; Mira Jung; Sung A Lee; Theresa Carr; Anne-Kristin Fentz; Joerg Spangenberg; Carsten Zornig; Hartmut H Juhl; Kerstin A David
Journal:  Biotechniques       Date:  2004-06       Impact factor: 1.993

2.  Variable specimen handling affects hormone receptor test results in women with breast cancer: a large multihospital retrospective study.

Authors:  Flory L Nkoy; M Elizabeth H Hammond; William Rees; Tom Belnap; Braden Rowley; Steve Catmull; William Sause
Journal:  Arch Pathol Lab Med       Date:  2010-04       Impact factor: 5.534

3.  Determination of phosphorylated proteins in tissue specimens requires high-quality samples collected under stringent conditions.

Authors:  Corinna Wolf; Tiantom Jarutat; Suzana Vega Harring; Kristin Haupt; Galina Babitzki; Sabine Bader; Kerstin David; Hartmut Juhl; Susanne Arbogast
Journal:  Histopathology       Date:  2013-11-23       Impact factor: 5.087

4.  Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

Authors:  Robert J Motzer; Konstantin Penkov; John Haanen; Brian Rini; Laurence Albiges; Matthew T Campbell; Balaji Venugopal; Christian Kollmannsberger; Sylvie Negrier; Motohide Uemura; Jae L Lee; Aleksandr Vasiliev; Wilson H Miller; Howard Gurney; Manuela Schmidinger; James Larkin; Michael B Atkins; Jens Bedke; Boris Alekseev; Jing Wang; Mariangela Mariani; Paul B Robbins; Aleksander Chudnovsky; Camilla Fowst; Subramanian Hariharan; Bo Huang; Alessandra di Pietro; Toni K Choueiri
Journal:  N Engl J Med       Date:  2019-02-16       Impact factor: 91.245

5.  MicroRNA: Biogenesis, Function and Role in Cancer.

Authors:  Leigh-Ann Macfarlane; Paul R Murphy
Journal:  Curr Genomics       Date:  2010-11       Impact factor: 2.236

6.  Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.

Authors:  Ankur Sharma; Elaine Yiqun Cao; Vibhor Kumar; Xiaoqian Zhang; Hui Sun Leong; Angeline Mei Lin Wong; Neeraja Ramakrishnan; Muhammad Hakimullah; Hui Min Vivian Teo; Fui Teen Chong; Shumei Chia; Matan Thangavelu Thangavelu; Xue Lin Kwang; Ruta Gupta; Jonathan R Clark; Giridharan Periyasamy; N Gopalakrishna Iyer; Ramanuj DasGupta
Journal:  Nat Commun       Date:  2018-11-22       Impact factor: 14.919

7.  Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial.

Authors:  Robert J Motzer; Paul B Robbins; Thomas Powles; Laurence Albiges; John B Haanen; James Larkin; Xinmeng Jasmine Mu; Keith A Ching; Motohide Uemura; Sumanta K Pal; Boris Alekseev; Gwenaelle Gravis; Matthew T Campbell; Konstantin Penkov; Jae Lyun Lee; Subramanian Hariharan; Xiao Wang; Weidong Zhang; Jing Wang; Aleksander Chudnovsky; Alessandra di Pietro; Amber C Donahue; Toni K Choueiri
Journal:  Nat Med       Date:  2020-09-07       Impact factor: 53.440

8.  Molecular Tumor Boards: Ethical Issues in the New Era of Data Medicine.

Authors:  Henri-Corto Stoeklé; Marie-France Mamzer-Bruneel; Charles-Henry Frouart; Christophe Le Tourneau; Pierre Laurent-Puig; Guillaume Vogt; Christian Hervé
Journal:  Sci Eng Ethics       Date:  2017-03-09       Impact factor: 3.525

9.  Comprehensive analysis of normal adjacent to tumor transcriptomes.

Authors:  Dvir Aran; Roman Camarda; Justin Odegaard; Hyojung Paik; Boris Oskotsky; Gregor Krings; Andrei Goga; Marina Sirota; Atul J Butte
Journal:  Nat Commun       Date:  2017-10-20       Impact factor: 14.919

Review 10.  Exosomes: key players in cancer and potential therapeutic strategy.

Authors:  Jie Dai; Yangzhou Su; Suye Zhong; Li Cong; Bang Liu; Junjun Yang; Yongguang Tao; Zuping He; Chao Chen; Yiqun Jiang
Journal:  Signal Transduct Target Ther       Date:  2020-08-05
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  4 in total

1.  Editorial: Biomarker Detection Algorithms and Tools for Medical Imaging or Omics Data.

Authors:  William C Cho; Fengfeng Zhou; Jie Li; Lin Hua; Feng Liu
Journal:  Front Genet       Date:  2022-05-25       Impact factor: 4.772

2.  Colorectal cancer concurrent gene signature based on coherent patterns between genomic and transcriptional alterations.

Authors:  Ming-Hung Shen; Chi-Jung Huang; Thien-Fiew Ho; Chih-Yi Liu; Ying-Yih Shih; Ching-Shui Huang; Chi-Cheng Huang
Journal:  BMC Cancer       Date:  2022-05-30       Impact factor: 4.638

Review 3.  The Role of Histology-Agnostic Drugs in the Treatment of Metastatic Castration-Resistant Prostate Cancer.

Authors:  Giovanni Maria Iannantuono; Francesco Torino; Roberto Rosenfeld; Simona Guerriero; Manuela Carlucci; Stefano Sganga; Barbara Capotondi; Silvia Riondino; Mario Roselli
Journal:  Int J Mol Sci       Date:  2022-08-01       Impact factor: 6.208

4.  COLONOMICS - integrative omics data of one hundred paired normal-tumoral samples from colon cancer patients.

Authors:  Anna Díez-Villanueva; Rebeca Sanz-Pamplona; Xavier Solé; David Cordero; Marta Crous-Bou; Elisabet Guinó; Adriana Lopez-Doriga; Antoni Berenguer; Susanna Aussó; Laia Paré-Brunet; Mireia Obón-Santacana; Ferran Moratalla-Navarro; Ramon Salazar; Xavier Sanjuan; Cristina Santos; Sebastiano Biondo; Virginia Diez-Obrero; Ainhoa Garcia-Serrano; Maria Henar Alonso; Robert Carreras-Torres; Adria Closa; Víctor Moreno
Journal:  Sci Data       Date:  2022-10-01       Impact factor: 8.501

  4 in total

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