Evaluation of Sensory Loss Obtained by Circum-Psoas Blocks in Patients Undergoing Total Hip Replacement: A Descriptive Pilot Study.

Purpose: The transversalis fascia (TF) encases the quadratus lumborum and psoas major (PM) muscles, respectively, after they split caudalward approximately at the level of the iliac crest. The branches of the lumbar plexus variably exit medially and laterally from the TF-encased PM muscle. We hypothesized that the local anesthetic (LA) injections around the anterolateral edge of PM at the supra-iliac level and into the retro-psoas compartment at the L5/S1 level, which termed as the circum-psoas blocks, could block the lumbar plexus branches. Therefore, here we evaluated the sensory loss caused by the circum-psoas blocks.
Methods: A total of 26 patients scheduled for total hip replacement were recruited for the study. After anesthesia induction, the ultrasound-guided circum-psoas blocks were performed in the lateral position with the affected side upward, in which the 0.3% ropivacaine was injected posterior to the TF and around the anterolateral edge of PM muscle at the supra-iliac level (25 mL), and into the retro-psoas compartment at the L5/S1 level (20 mL). The sensory block dermatomes and the muscle strength of quadriceps femoris were evaluated at 2 h or 6 h after surgery, respectively. The postoperative pain scores and opioid consumption were recorded.
Results: The median (interquartile range) highest and lowest dermatomes of sensory block were T10 (T9-T10) and S2 (S2-S2), respectively. The muscle strength of the quadriceps femoris evaluated at 6 h post-surgery was 4 (4-5) points. Total postoperative equivalent milligrams of oral morphine consumption in the first 24 h were 11.3 ± 3.6 mg.
Conclusion: The circum-psoas blocks may be a promising approach for postoperative analgesia of hip surgery, since they provide a dermatomal coverage of sensory block from T8-11 to S1-3. Clinical Trial Registration: Chinese Clinical Trial Registry, clinical trial number ChiCTR2100051247.

Introduction

To provide the complete sensory loss for total hip replacement surgery, the blockade of the branches of both lumbar and sacral plexuses is required, although there remains no single technique that reliably acquires this.1 The transversalis fascia (TF) encases the quadratus lumborum and psoas major (PM) muscles, respectively, after they split caudalward approximately at the level of the iliac crest.2 The main nerve branches of the lumbar plexus, including the femoral nerve, lateral femoral cutaneous nerve (LFCN), and obturator nerve, are located within the PM compartment.3–5 These nerve branches of the lumbar plexus variably exit medially and laterally from the TF-encased PM muscle to the retro-psoas compartment (obturator nerve) and the iliopsoas compartment (femoral nerve and LFCN), respectively.6–9 The sacral plexus originates from the lumbosacral trunk (L4–L5) and the anterior rami of the S1–S3 nerve roots. The obturator nerve arises from the anterior rami of the second, third, and fourth lumbar nerves and descends through the PM muscle. It emerges from the medial border of PM muscle and then runs along the lateral wall of the lesser pelvis. In the retro-psoas compartment, the lumbosacral trunk is found located medially to the obturator nerve.6,9 More caudally, the retro-psoas compartment is anatomically continuous with the compartment between the piriformis and pelvic presacral fascia.

Based on the anatomical analysis, we speculated that if the local anesthetic (LA) was injected posterior to the psoas fascia (TF) and around the anterolateral edge of PM muscle just cranial to the iliac crest under ultrasound guidance, the two main branches of lumbar plexus (femoral nerve and LFCN) would be blocked. Additionally, the cranial spread of LA injected along the TF may lead to the lower thoracic paravertebral block via the medial arcuate ligament.10–12 On the other hand, another branch of lumbar plexus, the obturator nerve, and lumbosacral trunk could be blocked if the LA is injected into the retro-psoas compartment and around the posterior edge of PM muscle at the L5/S1 level.6,9 We termed the simple procedures as the circum-psoas blocks, since the LA was placed around the anterolateral and posterior edges of PM muscle at the supra-iliac and L5/S1 levels, respectively.13 In the current study, we aimed to evaluate the sensory loss obtained by the circum-psoas blocks in patients undergoing total hip replacement.

Methods

Ethical approval for this study (2021-ke-504) was provided by the Ethical Committee of Beijing Chaoyang Hospital, Capital Medical University, China. This clinical trial was registered with the Chinese Clinical Trial Registry, clinical trial number ChiCTR2100051247, date of registration September 16, 2021. Patients scheduled for total hip replacement under general anesthesia at our hospital were enrolled between September 22, 2021, and November 28, 2021. The written informed consents were obtained from all patients. Overall, our study complies with the Declaration of Helsinki.

A total of 26 participants between 50 and 80 years of age with a body mass index (BMI) of 20–30 kg m−2 and an American Society of Anesthesiologists (ASA) physical status of I–III were eligible for inclusion (Figure 1). Patients with a reported history of the use of any analgesic drugs for >3 months, allergy to medications used in our protocol, local or systemic infections, inability to accurately comprehend or take part in pain assessments due to psychiatric disorders, and the narrow distance between L5 transverse process and sacral ala (less than 1 cm in the anteroposterior X-ray film) were excluded. Patient demographic details, including age, sex, height, and weight, were recorded.

Figure 1

A flow chart showing patient progress through the study phases.

A standardized anesthetic regimen was performed in patients. Briefly, after the patient entered the operating room, the noninvasive blood pressure, electrocardiography, pulse oxygen saturation, and end-tidal carbon dioxide were monitored. Peripheral venous access was established. Next, an invasive radial arterial line was placed. General anesthesia was then induced by administering intravenous propofol 1.5–2 mg kg−1 (Fresenius Kabi AB, Uppsala, Sweden), sufentanil 0.2 μg kg-1 (Yichang Renfu Pharma, Yichang, China), and rocuronium 0.8 mg kg-1 (Xianju Pharma, Xianju, China). Then, the laryngeal mask was inserted, and the mechanical ventilation was initiated. General anesthesia was maintained through a steady infusion of propofol (0.08–0.1 mg kg−1 min−1) and remifentanil (0.1–0.2 μg kg−1 min−1, Yichang Renfu Pharma, Yichang, China).

The patients were placed in the lateral decubitus position with the affected upward after the laryngeal mask insertion. Then, after necessary skin sterilization, we performed the circum-psoas injections just cranial to the iliac crest level, in which the LA was injected posterior to the TF and around the anterolateral edge of PM muscle under ultrasound guidance. In detail, a curved array transducer (KONICA Minolta, Tokyo, Japan) was placed in the transverse position immediately cranial to the iliac crest at the posterior axillary line level. The quadratus lumborum muscle is identified with its attachment to the lateral edge of the transverse process of the lumbar vertebrae and a shamrock sign can be clearly seen in the sonogram.14 Then, a 10 cm puncture needle was then inserted from the lateral transducer edge in the plane of the ultrasound beam in a posterolateral to medial direction until the tip of the needle penetrated the TF of the anterolateral edge of the PM muscle (Figure 2). Proper needle positioning was confirmed by observing the fluid distribution around the PM muscle beneath the TF after injecting a small volume of 0.9% saline (5 mL). Then, 0.3% of ropivacaine (25 mL) was gradually injected into the fascial compartment to form a nearly 1/3 ring around the anterolateral edge of PM muscle after repeated negative aspiration ().

Figure 2

The circum-psoas injection at the supra-iliac level and LA spread. To perform the circum-psoas block at the supra-iliac level, the transducer was placed at the posterior axillary line to perform the transverse scan (embedding graph) and the needle was inserted in-plane in a posterior-to-anterior direction, penetrating the QL and psoas fascia under a shamrock pattern image. The LA was finally injected between psoas fascia and the substance of PM muscle and formed a lunar-shaped spread around the anterior-lateral aspect of PM muscle.

Then, we performed the retro-psoas compartment block at the L5/S1 intervertebral level, in which the LA is placed around the posterior edge of the PM muscle.6,9 The transducer was first placed in the lumbosacral region to perform the paramedian sagittal scan on the affected side. After the sacrum and the L5 transverse process were identified, the transducer was rotated to the paramedian transverse plane until the spinal process and laminae of L5 and the iliac bone became visible in the sonogram. The lumbosacral ligament and the intertransverse ligament between the laminae of L5 and iliac bone were seen in the sonogram (Figure 3). The block needle was inserted with a steep out-of-plane approach penetrating the erector spinae muscle, the intertransverse ligament, the osteofibrotic tunnel and the lumbosacral ligament. Proper needle positioning was confirmed by injecting small (2–5 mL) aliquots of 0.9% saline. Ropivacaine (20 mL; 0.3%) was then gradually injected after repeated negative aspiration. A distinct loss-of-resistance during injection and view of the tip when the needle tip penetrated the lumbosacral ligament were considered as the primary endpoint.

Figure 3

The circum-psoas injection at the L5/S1 intervertebral level. To perform the circum-psoas block at the L5/S1 intervertebral level, the transducer was placed to perform the paramedian transverse scan (embedding graph) and the needle was inserted out-of-plane in a posterior-to-anterior direction, penetrating the intertransverse ligament and lumbosacral ligament. The LA was finally injected into the retro-psoas compartment and around the posterior aspect of PM muscle.

All patients received surgery for total hip replacement in the lateral position. Additional intraoperative rocuronium boluses were administered as appropriate. When the surgery was finished, intravenous neostigmine (40 μg kg-1; Shanghai Xinyijinzhu Pharma, Shanghai, China) was administered to reverse the neuromuscular blockade. The total duration of anesthesia from intubation to extubation was recorded. After surgery, patients were transferred to the postanesthesia care room, where they achieved complete anesthetic recovery. A numerical rating scale (NRS) was used to gauge pain severity while at rest and during movement (0 = “no pain,” 10 = “worst pain imaginable”). The patients received the standard postoperative analgesia regimen. Celecoxib 200 mg was given orally every 12 hours. In addition, oral oxycodone 5–10 mg was given every 4 hours to patients with NRS score ≥4.15 The cumulative opioid consumption at 24 h was expressed as equivalent milligrams of oral morphine using a conversion factor of 1.5 for oxycodone. Postoperative pain was evaluated at 2 h, 6 h, 12 h, and 24 h. Possible adverse effects, including nausea and vomiting, dizziness, and pruritus, were recorded.

An investigator assessed sensory block levels using a cool roller at 2 h postoperatively. Normal sensation on the shoulder was used for comparison. The sensory block was identified when the sensation of cold was lost or markedly reduced. Dermatomes of thoracic spinal nerves were tested at the anterior axillary line. Dermatome L1 was tested 2 cm below the midpoint of the inguinal ligament, L2 at the midpoint of the anterior side of the thigh, L3 at the midpoint of the patella, L4 at the midpoint of the medial leg, L5 at the midpoint of the dorsum of the foot, S1 at the lateral side of the fifth toe, S2 at the midpoint of the popliteal crease and S3 at the ischial tuberosity.16

The muscle strength of the quadriceps femoris was assessed at 6 h after surgery. Patients were asked to flex their hips and knees, and their muscle strength was scored as follows: no muscle contraction, 0 points; muscle contraction but no joint movement, 1 point; joint movement but no gravity resistance, 2 points; gravity resistance, 3 points; gravity and partial counterforce resistance, 4 points; and normal joint function, 5 points.17 These scores were independently given by another anesthetist.

Statistical Analysis

The sample size was empirically identified, since this was a pilot study. The previous literature indicated that a sample size of 10–40 is appropriate.18 In the current study, an initial goal of 22 patients was set. After considering a drop-out rate of 20%, the goal sample size was revised to 26 patients. Categorical variables are presented as number and frequency. Continuous variables showing normality are expressed as mean ± standard deviation, whereas those not showing normality are expressed as median values [25th–75th interquartile range (IQR)]. SPSS software (version 22.0, IBM Corporation, Armonk, NY, USA) was used for statistical analysis.

Results

In total, 26 patients were recruited for this study. After excluding one patient who declined to participate, we enrolled 25 (13 men and 12 women) patients who received the circum-psoas blocks. One patient was excluded because he developed the delirium after surgery. The study flow chart is shown in Figure 1.

The patients’ demographics and operation details are presented in Table 1. The patients had a mean age of 70.5 (6.5) yr, weight 59.2 (5.7) kg, height 162.1 (6.7) cm, and BMI 26.4 (3.1). The average anesthesia and operation duration were 123 ±19 min, and 94 ± 11 min, respectively.

Table 1

Demographics and Operation Details

Variables	Patients (n = 24)
Age (year)	70.5 ± 6.5
Sex [n (%)]
Male	13 (54.2%)
Female	11 (45.8%)
Height (cm)	162.1 ± 6.7
Weight (kg)	59.2 ± 5.7
Body mass index	26.4 ± 3.1
ASA [n (%)]
I–II	16 (66.7%)
III	8 (33.3%)
Operation time (min)	94 ± 11
Anesthesia time (min)	123 ± 19

Notes: Continuous data are presented as mean ± standard deviation or median (interquartile range). Nominal data are presented as number (percentage).

Abbreviation: ASA, American Society of Anesthesiologist physical status.

The dermatomal coverage of the sensory block was tested at 2 h after surgery. The median (IQR) highest and lowest sensory levels were T10 (T9–T10) and S2 (S2–S2), respectively. The mean number of blocked dermatomes was 10.2 ± 0.8. The sensory blockade range from T11 – S1 was obtained in every patient (Figure 4). Two patients achieved coverage as cephalad as T8 and 2 patients achieved coverage as caudal as S3.

Figure 4

The sensory block probability of different dermatomes in patients. The patients reported a dermatomal coverage of sensory block with the highest level of T8 and the lowest level of S3 at 2 hour after surgery. The sensory blockade range of T11–S2 was obtained in every patient.

The muscle strength of the quadriceps femoris evaluated at 6 h post-surgery was 4 (4–5) [median (IQR)]. 41.7% patients acquired the 5 points in muscle strength scoring. The 3 points was given in 12.7% patients. No patients had the points less than 3 (Table 2).

Table 2

The Postoperative Data

	Patients (n = 24)
Total postoperative oral morphine equivalent consumption in the first 24 h (mg)	11.3 ± 3.6
Postoperative pain intensity at rest, Median (IQR)
NRS at 2 h	1.8 ± 1.1
NRS at 6 h	1.5 ± 0.9
NRS at 12 h	1.4 ± 0.7
NRS at 24 h	1.3 ± 0.6
Postoperative pain intensity on movement, Median (IQR)
NRS at 2 h	3.7 ± 2.0
NRS at 6 h	3.9 ± 2.2
NRS at 12 h	3.3 ± 2.1
NRS at 24 h	2.3 ± 1.8
Muscle strength of quadriceps femoris evaluated at 6 h after surgery [n (%)]
0–2 points	0
3 points	3 (12.5%)
4 points	11 (45.8%)
5 points	10 (41.7%)
Postoperative nausea [n (%)]	2 (8.3%)
Episodes of vomiting [n (%)]	1 (4.2%)
Pruritus [n (%)]	1 (4.2%)

Notes: Normally distributed variables are expressed as mean ± standard deviation. Non-normally distributed variables are expressed as median (IQR). Categorical variables are expressed as number (percentage). Opioid consumption is expressed as equivalent milligrams of oral morphine.

Abbreviations: NRS, numerical rating scale; IQR, interquartile range.

The postoperative pain scores were shown in (Table 2). Total postoperative equivalent milligrams of oral morphine consumption in the first 24 h were 11.3 ± 3.6 mg (Table 2). No patients required additional rescue analgesics in the first 24 h after surgery.

Two patients suffered from the nausea, 1 patient had vomiting and 1 patient developed pruritus during the first 24 h after surgery.

Discussion

In this prospective observational study, the circum-psoas injections at the two different levels could acquire the dermatomal coverage of sensory block from T8–11 to S1–3, which was detected at 2 h after surgery. Moreover, the NRS pain scores at rest and on movement, and postoperative opioid consumption were kept at the relatively lower levels during the first 24 postoperative hours, while the muscle strength of quadriceps femoris was little affected by the blocks.

Three mechanisms may be involved in the blocking actions of the circum-psoas blocks. First, the sub-endothoracic compartment (thoracic paravertebral space) communicates with the compartment between the TF and PM muscles.10–12 It indicates that the LA injected into the compartment around the PM muscle at the supra-iliac level may spread cranially into the lower thoracic paravertebral space. Second, the main branches of lumbar plexus, such as LFCN, femoral and obturator nerves, anatomically emerge lateral and medial to PM muscle encased by the TF at variable levels.4,13,19 Therefore, the LA injected into the compartment around the anterolateral border of PM muscle at the supra-iliac level may spread caudally and laterally to block the LFCN and the femoral nerves. Finally, the LA injected into the compartment around and posterior to the PM muscle at the L5/S1 level can block the lumbosacral trunk and obturator nerve, since these nerves are located in the same compartment.6,7,9 Additionally, the LA may also spread caudally to block the more sacral nerves, if the volume given is high enough.

Postoperative analgesia of total hip replacement surgery involves a wide range of nerves, including the obturator nerve and the femoral nerve in front of the hip joint, the superior gluteal nerve and the sciatic nerve behind the hip joint, the iliohypogastric nerve, the subcostal nerve, and the LFCN around the incision as well as the dorsal branch of L1/2/3 and S1/2/3 spinal nerves. In this observational study, we found that the LA injected around the PM muscle at two different levels could acquire the dermatomal coverage of sensory block from T8–11 to S1–3, which was detected at 2 h after surgery. The wider dermatomal coverage of circum-psoas block can almost provide the complete analgesia for hip surgery. The average anesthesia and operation duration were 123 ±19 min, and 94 ± 11 min, respectively. In order to ensure the complete recovery of cognitive function from the general anesthesia in patients, we chose to evaluate the sensory loss coverage at 2 h after blocks. As a result, the reported sensory block in patients was reliable.

Previous study has shown that the patients undergoing total hip replacement had moderate pain on movement (NRS > 4) at 6 h after surgery, even if receiving local infiltration analgesia, which may delay the hip exercise and enhanced recovery.15,17 Our data demonstrated that the circum-psoas blocks can provide better postoperative pain relief at rest or during movement and are associated with the lower demand for postoperative opioid in the first 24 h after surgery.

The muscle strength was measured during the first active motion at 6 h after surgery. In the current study, the circum-psoas blocks did not cause serious quadriceps femoris muscle weakness. 87.5% of patients had more than 3 points, and only 12.5% of patients acquired the 3 points. Ropivacaine at the low concentration could present the sensory block, but has no or a limited effect on motor nerves, thus preserving the ability to muscle strength. The lower concentration of ropivacaine (0.3%) we used for the circum-psoas blocks may explain why a sensory, but not motor block occurred.

The posterior approach for psoas compartment block has been used to provide pain management for the hip surgery. However, the risk of inadvertent neuraxial block or injury to vital vascular structures and organs, and the need for neurostimulation and ultrasound guidance have decreased popularity.3,8,15,19 The circum-psoas block has some advantages over the other blocks used for the hip surgery. First, it belongs to the interfascial plane block and can be performed under ultrasound guidance alone and without using neurostimulation. Second, the blocks have wider dermatomal coverage of sensory block and provide almost complete analgesia for hip surgery. Third, unlike the psoas compartment block, the circum-psoas blocks have reliable efficacy for obturator nerve blockade.4,6,7 On the other hand, the sacral plexus block is often used for the hip surgery together with the lumbar plexus block. Variations in the relationship between the sciatic nerve and piriformis muscle can influence the efficacy of sacral plexus block.20–22 Additionally, the LA deposit compartment for sacral plexus block is adjacent to the surgical area. A part of LA is possibly drained away during the surgical dissection, thus affecting the acting duration of the block. In contrast, the injection target with the circum-psoas block (retro-psoas compartment) is far away from the surgical area. Moreover, in the current study, the circum-psoas blocks present the 100% of block probability for the L4, L5, and S1 spinal nerves and 83.3% of block probability for the S2 spinal nerve. It provides most of the dermatomal coverage of sacral plexus block.

This study has several limitations. Sensory areas were assessed postoperatively, and a previous study demonstrated sensory ranges regressing over time.23 Hence, our results may be less than the maximum height and range. Due to incisions and dressings, we could not evaluate the blocked area as a plane, but only on the representative longitudinal lines. We only included the patients with BMI < 30 kg/m2. Future studies should evaluate the utility of the technique we described above in the obese patients. Additionally, this study is descriptive but not a randomized trial. The comparisons between this technique and the other blocks should be implemented in the future.

Conclusion

In summary, we have demonstrated the successful use of the circum-psoas blocks at the supra-iliac and the L5/S1 intervertebral levels. The circum-psoas blocks are characterized by wider dermatomal coverage of sensory blockade, ease of performance and little-affected muscle strength of quadriceps femoris. Further, randomized trials are needed to compare the circum-psoas blocks with other blocks to improve the surgical outcomes.