Dilek Gogas Yavuz1, Kadriye Aydin2, Tugce Apaydin3, Arzu Velioglu4, Meral Mert5, Zafer Pekkolay6, Ergun Parmaksiz7, Meral Mese7, Ayse Esen Pazir8, Emre Aydın9, Onur Bugdayci10, Serhan Tuglular4. 1. Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey. 2. Department of Endocrinology and Metabolism, Kartal Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey. 3. Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey. tugce.apaydin@marmara.edu.tr. 4. Department of Nephrology, Marmara University School of Medicine, Istanbul, Turkey. 5. Department of Endocrinology and Metabolism, Istanbul Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey. 6. Department of Endocrinology and Metabolism, Dicle University School of Medicine, Diyarbakır, Turkey. 7. Department of Nephrology, Kartal Lutfi Kirdar Research and Training Hospital, Istanbul, Turkey. 8. Department of Nephrology, Istanbul Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey. 9. Department of Nephrology, Dicle University School of Medicine, Diyarbakır, Turkey. 10. Department of Radiology, Marmara University School of Medicine, Istanbul, Turkey.
Abstract
PURPOSE: Kidney transplant recipients are prone to metabolic bone diseases and consequent fractures. This study aimed to evaluate the incidence of incipient vertebral fractures, osteopenia, osteoporosis, and the clinical factors associated with incipient vertebral fractures in a group of kidney transplant patients. METHODS: Two hundred sixty-four patients (F/M 124/140, 45.3 ± 13 years) who had undergone kidney transplantation in tertiary care centers were included. Vertebral fractures were assessed semiquantitatively using conventional thoracolumbar lateral radiography in 202 of the patients. RESULTS: Vertebral fractures were observed in 56.4% (n = 114) of the study group. The frequency of osteoporosis was 20.0% (53 of 264 patients), and osteopenia was 35.6% (94 of 264 patients). Bone mineral density (BMD) levels were in the normal range in 40.3% (n = 46) of the subjects with vertebral fractures. It was in the osteoporotic range in 20.1% (n = 23) and the osteopenic range in 40.3% (n = 46). Vertebral fractures were associated with age, duration of hemodialysis, BMI, and femoral neck Z score (R2 37.8%, p = 0.027). CONCLUSION: As incipient vertebral fractures can be observed in patients with normal BMD levels in kidney transplant recipients, conventional X-ray screening for vertebral fractures may be beneficial for a proper therapy decision of metabolic bone disease in kidney transplant recipients.
PURPOSE: Kidney transplant recipients are prone to metabolic bone diseases and consequent fractures. This study aimed to evaluate the incidence of incipient vertebral fractures, osteopenia, osteoporosis, and the clinical factors associated with incipient vertebral fractures in a group of kidney transplant patients. METHODS: Two hundred sixty-four patients (F/M 124/140, 45.3 ± 13 years) who had undergone kidney transplantation in tertiary care centers were included. Vertebral fractures were assessed semiquantitatively using conventional thoracolumbar lateral radiography in 202 of the patients. RESULTS: Vertebral fractures were observed in 56.4% (n = 114) of the study group. The frequency of osteoporosis was 20.0% (53 of 264 patients), and osteopenia was 35.6% (94 of 264 patients). Bone mineral density (BMD) levels were in the normal range in 40.3% (n = 46) of the subjects with vertebral fractures. It was in the osteoporotic range in 20.1% (n = 23) and the osteopenic range in 40.3% (n = 46). Vertebral fractures were associated with age, duration of hemodialysis, BMI, and femoral neck Z score (R2 37.8%, p = 0.027). CONCLUSION: As incipient vertebral fractures can be observed in patients with normal BMD levels in kidney transplant recipients, conventional X-ray screening for vertebral fractures may be beneficial for a proper therapy decision of metabolic bone disease in kidney transplant recipients.
Authors: K Falkiewicz; M Boratyńska; S C Zmonarski; A Milewicz; D Patrzałek; P Biecek; M Klinger Journal: Transplant Proc Date: 2009-10 Impact factor: 1.066
Authors: W Y Park; S Han; B S Choi; C W Park; C W Yang; Y-S Kim; J I Kim; I S Moon; B H Chung Journal: Transplant Proc Date: 2017-06 Impact factor: 1.066
Authors: S Pereira; S Pedroso; L Martins; P Santos; M Almeida; C Freitas; L Dias; J Dores; R Almeida; A Castro Henriques; M Teixeira Journal: Transplant Proc Date: 2010-03 Impact factor: 1.066