The neuropsychological implications of allergenic clinical titration in the treatment of allergic diseases.

The wheal is used for assessment of the Provocation-Neutralisation Response in Clinical Titration. It is the third, slowest, and most indirect measure of the Antigen-Antibody Reaction as demonstrated in the Triple Response. The flare is produced by an axone reflex. It appears rapidly as a direct neurological response to antigen challenge. It is associated with local changes in Direct Current Potential. These are transmitted distally through the d.c. Perineural Analogue System. Neutralisation values appear in a harmonic series with increasing dilutions of antigen. Passive Allergenic Neutralisation does not require active antigen administration into the patient's tissues. Passive Neutralisation can be performed in the absence of allergenic material. It is concluded that the wheal need not be associated with the Provocation-Neutralisation technique, and that a neuropsychological basis for the Provocation-Neutralisation response should be explored.