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Literature DB >> 3537614

Adverse reactions and interactions with newer cephalosporin and cephamycin antibiotics.

Abstract

In this review, adverse reactions and interactions associated with the use of the newer cephalosporins and cephamycins are surveyed; special emphasis is placed on those reactions specific for some of these newer agents, namely disulfiram-like reactions with alcohol, effects on prothrombin synthesis, and lower gastrointestinal tract reactions. It is apparent that cephalosporins with a 3-methylthiotetrazole side-chain in the cephem nucleus cause clinically significant side effects more frequently than those without such a moiety. While still having a high degree of safety, cephalosporins with this chemical structure clearly have a higher degree of toxicity than those without this side-chain.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1986 PMID： 3537614 DOI： 10.1007/BF03259826

Source DB: PubMed Journal: Med Toxicol ISSN： 0112-5966

75 in total

Adverse reactions and interactions with newer cephalosporin and cephamycin antibiotics.

1. Cephaloridine, cephalothin and the kidney.

2. Interaction between cephalosporins and alcohol.

3. [A new cause of acute avitaminosis K: lamoxactam].

4. Cefoxitin-associated exfoliative dermatitis.

5. On the disulfiram-like activity of moxalactam.

6. Coagulopathy associated with broad spectrum antibiotic therapy.

7. Antibiotic-associated colitis during moxalactam therapy.

8. Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy.

9. [Effects of cephem antibiotics on ethanol metabolism].

10. Penicillin allergy: clinical experience with a battery of skin-test reagents.

Review 1. Antibacterial-induced nephrotoxicity in the newborn.

2. Anti-anaerobic antimicrobial agents: cefoxitin, cefotetan, clindamycin, and metronidazole.

3. [Effectiveness and tolerance of cefixime in the treatment of acute pyelonephritis].

Review 4. Clinical features, pathogenesis and management of drug-induced seizures.

Review 5. Antibiotics in neonatal infections: a review.

Review 6. Ceftibuten pharmacokinetics and pharmacodynamics. Focus on paediatric use.

7. Synergy and Mode of Action of Ceftazidime plus Quercetin or Luteolin on Streptococcus pyogenes.