Céline N Heinz1, Amelie Echle1, Sebastian Foersch2, Andrey Bychkov3, Jakob Nikolas Kather1,4,5. 1. Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany. 2. Department of Pathology, University Medical Center Mainz, Mainz, Germany. 3. Department of Pathology, Kameda Medical Center, Kamogawa, Chiba, Japan. 4. Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany. 5. Pathology and Data Analytics, Leeds Institute of Medical Research at St James', University of Leeds, Leeds, UK.
Abstract
AIMS: Artificial intelligence (AI) provides a powerful tool to extract information from digitised histopathology whole slide images. During the last 5 years, academic and commercial actors have developed new technical solutions for a diverse set of tasks, including tissue segmentation, cell detection, mutation prediction, prognostication and prediction of treatment response. In the light of limited overall resources, it is presently unclear for researchers, practitioners and policymakers which of these topics are stable enough for clinical use in the near future and which topics are still experimental, but worth investing time and effort into. METHODS AND RESULTS: To identify potentially promising applications of AI in pathology, we performed an anonymous online survey of 75 computational pathology domain experts from academia and industry. Participants enrolled in 2021 were queried about their subjective opinion on promising and appealing subfields of computational pathology with a focus upon solid tumours. The results of this survey indicate that the prediction of treatment response directly from routine pathology slides is regarded as the most promising future application. This item was ranked highest in the overall analysis and in subgroups by age and professional background. Furthermore, prediction of genetic alterations, gene expression and survival directly from routine pathology images scored consistently high throughout subgroups. CONCLUSIONS: Together, these data demonstrate a possible direction for the development of computational pathology systems in clinical, academic and industrial research in the near future.
AIMS: Artificial intelligence (AI) provides a powerful tool to extract information from digitised histopathology whole slide images. During the last 5 years, academic and commercial actors have developed new technical solutions for a diverse set of tasks, including tissue segmentation, cell detection, mutation prediction, prognostication and prediction of treatment response. In the light of limited overall resources, it is presently unclear for researchers, practitioners and policymakers which of these topics are stable enough for clinical use in the near future and which topics are still experimental, but worth investing time and effort into. METHODS AND RESULTS: To identify potentially promising applications of AI in pathology, we performed an anonymous online survey of 75 computational pathology domain experts from academia and industry. Participants enrolled in 2021 were queried about their subjective opinion on promising and appealing subfields of computational pathology with a focus upon solid tumours. The results of this survey indicate that the prediction of treatment response directly from routine pathology slides is regarded as the most promising future application. This item was ranked highest in the overall analysis and in subgroups by age and professional background. Furthermore, prediction of genetic alterations, gene expression and survival directly from routine pathology images scored consistently high throughout subgroups. CONCLUSIONS: Together, these data demonstrate a possible direction for the development of computational pathology systems in clinical, academic and industrial research in the near future.
Authors: Oliver Lester Saldanha; Hannah Sophie Muti; Heike I Grabsch; Rupert Langer; Bastian Dislich; Meike Kohlruss; Gisela Keller; Marko van Treeck; Katherine Jane Hewitt; Fiona R Kolbinger; Gregory Patrick Veldhuizen; Peter Boor; Sebastian Foersch; Daniel Truhn; Jakob Nikolas Kather Journal: Gastric Cancer Date: 2022-10-20 Impact factor: 7.701
Authors: Narmin Ghaffari Laleh; Daniel Truhn; Gregory Patrick Veldhuizen; Tianyu Han; Marko van Treeck; Roman D Buelow; Rupert Langer; Bastian Dislich; Peter Boor; Volkmar Schulz; Jakob Nikolas Kather Journal: Nat Commun Date: 2022-09-29 Impact factor: 17.694