Emilio Sánchez-Alvarez1, Manuel Macía2, Patricia de Sequera Ortiz3. 1. Department of Nephrology, Hospital Universitario de Cabueñes, Oviedo, Spain. 2. Department of Nephrology, Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. 3. Department of Nephrology, Hospital Universitario Infanta Leonor, Madrid, Spain.
Abstract
Background: The recent SARS-CoV-2 coronavirus pandemic has signified a significant effect on the health of the population worldwide. Patients on chronic RRT have been affected by the virus, and they are at higher risk due to the frequent comorbid conditions. Here, we show the results of the COVID-19 Registry of the Spanish Society of Nephrology during the first 6 weeks of the outbreak. Methods: This study is an analysis of the data recorded on a registry of patients with ESKD on RRT who tested positive for COVID-19. The aim was to evaluate clinical conditions, therapeutic management, and consequences, including outcome. The registry began on March 18th, 2020. It includes epidemiologic data, cause of CKD, signs and symptoms of the infection, treatments, and outcomes. Patients were diagnosed with SARS-CoV-2 infection on the basis of the results of PCR of the virus obtained from nasopharyngeal/oropharyngeal swabs. The tests were performed on symptomatic patients and on those who mentioned contact with infected patients. Results: As of May 2, the registry included data on 1397 patients (in-center hemodialysis [IC-HD], 63%; kidney transplant [Tx], 34%; peritoneal dialysis [PD], 3%; and home hemodialysis, 0.3%). The mean age was 67±15 years, and two-thirds were men. Dialysis vintage was 46±41 months, and the time after transplantation was 59±54 months. Eighty-five percent of the patients required hospital admission, and 8% had to be transferred to intensive care units. Overall mortality was 25% (IC-HD, 27%; Tx, 23%; and PD, 15%), and significant proportions of deceased patients have advanced age, are on IC-HD, and presented pneumonia. Age and pneumonia were independently associated with the risk of death. Conclusions: SARS-CoV-2 infection affected a significant number of Spanish patients on RRT, mainly those on IC-HD. Hospitalization rates and mortality were high. The factors more closely related to mortality were age and pneumonia.
Background: The recent SARS-CoV-2 coronavirus pandemic has signified a significant effect on the health of the population worldwide. Patients on chronic RRT have been affected by the virus, and they are at higher risk due to the frequent comorbid conditions. Here, we show the results of the COVID-19 Registry of the Spanish Society of Nephrology during the first 6 weeks of the outbreak. Methods: This study is an analysis of the data recorded on a registry of patients with ESKD on RRT who tested positive for COVID-19. The aim was to evaluate clinical conditions, therapeutic management, and consequences, including outcome. The registry began on March 18th, 2020. It includes epidemiologic data, cause of CKD, signs and symptoms of the infection, treatments, and outcomes. Patients were diagnosed with SARS-CoV-2 infection on the basis of the results of PCR of the virus obtained from nasopharyngeal/oropharyngeal swabs. The tests were performed on symptomatic patients and on those who mentioned contact with infected patients. Results: As of May 2, the registry included data on 1397 patients (in-center hemodialysis [IC-HD], 63%; kidney transplant [Tx], 34%; peritoneal dialysis [PD], 3%; and home hemodialysis, 0.3%). The mean age was 67±15 years, and two-thirds were men. Dialysis vintage was 46±41 months, and the time after transplantation was 59±54 months. Eighty-five percent of the patients required hospital admission, and 8% had to be transferred to intensive care units. Overall mortality was 25% (IC-HD, 27%; Tx, 23%; and PD, 15%), and significant proportions of deceased patients have advanced age, are on IC-HD, and presented pneumonia. Age and pneumonia were independently associated with the risk of death. Conclusions: SARS-CoV-2 infection affected a significant number of Spanish patients on RRT, mainly those on IC-HD. Hospitalization rates and mortality were high. The factors more closely related to mortality were age and pneumonia.
Authors: Jun Chen; Danping Liu; Li Liu; Ping Liu; Qingnian Xu; Lu Xia; Yun Ling; Dan Huang; Shuli Song; Dandan Zhang; Zhiping Qian; Tao Li; Yinzhong Shen; Hongzhou Lu Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban Date: 2020-05-25
Authors: Philippe Gautret; Jean-Christophe Lagier; Philippe Parola; Van Thuan Hoang; Line Meddeb; Morgane Mailhe; Barbara Doudier; Johan Courjon; Valérie Giordanengo; Vera Esteves Vieira; Hervé Tissot Dupont; Stéphane Honoré; Philippe Colson; Eric Chabrière; Bernard La Scola; Jean-Marc Rolain; Philippe Brouqui; Didier Raoult Journal: Int J Antimicrob Agents Date: 2020-03-20 Impact factor: 5.283
Authors: Borja Quiroga; María José Soler; Alberto Ortiz; Carlos Jesús Jaravaca Mantecón; Nathasha Nava Pérez; Marta Serra Martín; Yurika Sato; Antonio José Marin Franco; Diana Flor Pazmiño Zambrano; Rafael Lucena Valverde; Mayra Ortega Diaz; Carmen Calderón González; Juan Manuel Cazorla López; Mónica Pereira; Emilio González Parra; Ana Sánchez Horrillo; Carmen Sánchez González; Néstor Toapanta; Secundino Cigarrán Guldris; Rosa Sánchez Hernández; Soledad Pizarro Sánchez; María Muñiz Rincón; Nuria Garcia-Fernández; Natalia Blanco Castro; Rocío Collantes Mateo; Manuel Augusto Quiroz Morales; Beatriz Escamilla-Cabrera; Isabel Berdud Godoy; Beatriz Gil-Casares Casanova; Alba Leyva; José Rojas; Ron T Gansevoort; Patricia de Sequera Journal: Clin Kidney J Date: 2022-07-26