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Literature DB >> 3537196

Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions.

Abstract

The possibility that the distribution of skin lesions in some cutaneous diseases is due to variations in the antigenic properties of skin was investigated by mapping the expression of the skin-specific pemphigus vulgaris and bullous pemphigoid antigens in different regions of the body. The expression of both antigens was relatively stable within the same region, but varied between regions in a pattern that was distinct for each antigen. For each antigen there was a correlation between regions of high expression and location of skin lesions in autoimmune diseases involving the antigen. The results indicate that there are marked regional differences in the antigenic properties of skin and suggest this may influence the distribution of cutaneous lesions in some skin diseases.

Entities: Disease

Mesh：

Substances：
Antigens

Year: 1986 PMID： 3537196 PMCID： PMC2188484 DOI： 10.1084/jem.164.6.2125

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

7 in total

Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions.

1. Pemphigus foliaceus. Subcorneal intercellular antibodies of unique specificity.

2. Regional variation in the expression of bullous pemphigoid antigen and location of lesions in bullous pemphigoid.

3. Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia.

4. Bullous pemphigoid antigen synthesized in vitro by human epidermal cells.

5. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease.

6. Laminin and bullous pemphigoid antigen are distinct basement membrane proteins synthesized by epidermal cells.

7. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies.

1. Up-regulation of CCL11 and CCL26 is associated with activated eosinophils in bullous pemphigoid.

2. Role of plasminogen activator in pemphigus vulgaris.

3. Sweet's syndrome and myelodysplasia.

Review 4. Autoimmune bullous dermatoses in the elderly: diagnosis and management.

5. Autoimmune bullous dermatoses in the elderly: an update on pathophysiology, diagnosis and management.

6. Scalp involvement in pemphigus: a prognostic marker.

Review 7. The pathologies of bovine viral diarrhea virus infection. A window on the pathogenesis.