Literature DB >> 3536873

Fluphenazine-resistant Saccharomyces cerevisiae mutants defective in the cell division cycle.

K Matsumoto, I Uno, T Ishikawa.   

Abstract

An fls1 mutant of Saccharomyces cerevisiae, which did not grow in the presence of 30 micrograms of fluphenazine per ml, was isolated. Mutants that were resistant to 90 micrograms of fluphenazine per ml and temperature sensitive for growth were obtained from the fls1 mutant. One fluphenazine-resistance mutation, fsr1, was located near the his7 locus on chromosome II. Growth of the fsr1 mutants at 35 degrees C was arrested after nuclear division. The other group of fluphenazine-resistant mutants, carrying fsr2 mutations, showed Ca2+-dependent growth at 35 degrees C. Growth of the fsr2 mutants at 35 degrees C was arrested at the G2 stage of the cell cycle in Ca2+-poor medium.

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Year:  1986        PMID： 3536873      PMCID： PMC213645          DOI： 10.1128/jb.168.3.1352-1357.1986

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

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Authors:  B Weiss; R M Levin
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Authors:  L H Hartwell; R K Mortimer; J Culotti; M Culotti
Journal:  Genetics       Date:  1973-06       Impact factor: 4.562

3.  Damage of cellular functions by trifluoperazine, a calmodulin-specific drug.

Authors:  M Osborn; K Weber
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4.  Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae.

Authors:  K Matsumoto; I Uno; T Ishikawa
Journal:  J Bacteriol       Date:  1984-01       Impact factor: 3.490

5.  Altered calmodulin activity in fluphenazine-resistant mutant strains. Pleiotropic effect on development and cellular organization in Volvox carteri.

Authors:  N Kurn; B A Sela
Journal:  Eur J Biochem       Date:  1981-12

6.  Visualization of DNA in various phages (T4, chi, T7, phi 29) by ethidium bromide epi-fluorescent microscopy.

Authors:  T Kuroiwa; S Nishibayashi; S Kawano; T Suzuki
Journal:  Experientia       Date:  1981

7.  Characterization of a calmodulin-binding protein that is deficient in trifluoperazine-resistant variants of the macrophage-like cell line J774.

Authors:  M G Speaker; S J Orlow; T W Sturgill; O M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

8.  An enrichment method for auxotrophic yeast mutants using the antibiotic 'nystatin'.

Authors:  R Snow
Journal:  Nature       Date:  1966-07-09       Impact factor: 49.962

9.  Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae.

Authors:  Y Nogi; K Matsumoto; A Toh-e; Y Oshima
Journal:  Mol Gen Genet       Date:  1977-04-29

10.  Isolation and characterization of a phosphoprotein phosphatase-deficient mutant in yeast.

Authors:  K Matsumoto; I Uno; K Kato; T Ishikawa
Journal:  Yeast       Date:  1985-09       Impact factor: 3.239
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  2 in total

1.  Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable.

Authors:  T N Davis; J Thorner
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.

Authors:  S Yoshida; E Ikeda; I Uno; H Mitsuzawa
Journal:  Mol Gen Genet       Date:  1992-02
  2 in total

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