Chie Mogi1, Masanori Yoshida1, Koji Kawano1, Takaaki Fukuyama1, Toshiro Arai1. 1. Department of Animal Health Technology, Yamazaki University of Animal Health Technology, Tokyo, Japan (Mogi, Fukuyama); Hidamari Animal Hospital, Kanagawa, Japan (Yoshida); Tokyo Animal Allergy Center, Tokyo, Japan (Kawano); Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan (Arai).
Abstract
Objective: We aimed to examine the effects of cannabidiol (CBD)-containing hemp oil without delta-9-tetrahydrocannabinol (THC) as a supplemental treatment for canine atopic dermatitis (CAD), as well as its adverse effects, and effects on concurrent drug use in dogs. Animal: In this retrospective case series, 8 dogs with CAD were diagnosed by veterinary dermatologists certified by the Japanese Society of Veterinary Dermatology. Procedure: The medical records of dogs supplemented with CBD-containing hemp oil were evaluated with respect to signalment, physical examination, plasma C-reactive protein concentrations, pharmacologic management, the CAD Extent and Severity Index (4th iteration), and the Pruritus Visual Analog Scale. Results: Overall, CBD, used as a supplement in combination with other drugs, was well-tolerated over a wide dose range and decreased the occurrence of pruritus in dogs with CAD when ingested twice a day. Conclusion: This study provides the first report of supplementation with CBD without THC that was effective in controlling pruritic behavior in dogs with CAD. Clinical relevance: Further controlled studies are required to investigate the dose range, efficacy, and safety. Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Objective: We aimed to examine the effects of cannabidiol (CBD)-containing hemp oil without delta-9-tetrahydrocannabinol (THC) as a supplemental treatment for canine atopic dermatitis (CAD), as well as its adverse effects, and effects on concurrent drug use in dogs. Animal: In this retrospective case series, 8 dogs with CAD were diagnosed by veterinary dermatologists certified by the Japanese Society of Veterinary Dermatology. Procedure: The medical records of dogs supplemented with CBD-containing hemp oil were evaluated with respect to signalment, physical examination, plasma C-reactive protein concentrations, pharmacologic management, the CAD Extent and Severity Index (4th iteration), and the Pruritus Visual Analog Scale. Results: Overall, CBD, used as a supplement in combination with other drugs, was well-tolerated over a wide dose range and decreased the occurrence of pruritus in dogs with CAD when ingested twice a day. Conclusion: This study provides the first report of supplementation with CBD without THC that was effective in controlling pruritic behavior in dogs with CAD. Clinical relevance: Further controlled studies are required to investigate the dose range, efficacy, and safety. Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Authors: Luca Campora; Vincenzo Miragliotta; Emanuele Ricci; Luigia Cristino; Vincenzo Di Marzo; Francesco Albanese; Maria Federica Della Valle; Francesca Abramo Journal: Am J Vet Res Date: 2012-07 Impact factor: 1.156
Authors: Simona Pisanti; Anna Maria Malfitano; Elena Ciaglia; Anna Lamberti; Roberta Ranieri; Gaia Cuomo; Mario Abate; Giorgio Faggiana; Maria Chiara Proto; Donatella Fiore; Chiara Laezza; Maurizio Bifulco Journal: Pharmacol Ther Date: 2017-02-22 Impact factor: 12.310
Authors: Thierry Olivry; Manolis Saridomichelakis; Tim Nuttall; Emmanuel Bensignor; Craig E Griffin; Peter B Hill Journal: Vet Dermatol Date: 2014-01-25 Impact factor: 1.589