Margaux Roques1,2, Magali Raveneau3, Gilles Adam3, Amaury De Barros4, Isabelle Catalaa3, Sofia Patsoura3, Christophe Cognard3, Jean Darcourt3, Fabrice Bonneville3,5. 1. Department of Neuroradiology, Hôpital Pierre Paul Riquet CHU Purpan, Place du Docteur Baylac, TSA 40031, 31059, Toulouse, Cedex 9, France. margaux.roques@gmail.com. 2. Toulouse NeuroImaging Center (ToNIC), University of Toulouse Paul Sabatier INSERM, 31100, Toulouse, France. margaux.roques@gmail.com. 3. Department of Neuroradiology, Hôpital Pierre Paul Riquet CHU Purpan, Place du Docteur Baylac, TSA 40031, 31059, Toulouse, Cedex 9, France. 4. Department of Neurosurgery, Hôpital Pierre Paul Riquet CHU Purpan, Toulouse, France. 5. Toulouse NeuroImaging Center (ToNIC), University of Toulouse Paul Sabatier INSERM, 31100, Toulouse, France.
Abstract
PURPOSE: Despite a high variability, the hotspot method is widely used to calculate the cerebral blood volume (CBV) of glioblastomas on DSC-MRI. Our aim was to investigate inter- and intra-observer reproducibility of parameters calculated with the hotspot or a volume method and that of an original parameter assessing the fraction of pixels in the tumour volume displaying rCBV > 2: %rCBV > 2. METHODS: Twenty-seven consecutive patients with untreated glioblastoma (age: 63, women: 11) were retrospectively included. Three observers calculated the maximum tumour CBV value (rCBVmax) normalized with a reference ROI in the contralateral white matter (CBVWM) with (i) the hotspot method and (ii) with a volume method following tumour segmentation on 3D contrast-enhanced T1-WI. From this volume method, %rCBV > 2 was also assessed. After 8-12 weeks, one observer repeated all delineations. Intraclass (ICC) and Lin's (LCC) correlation coefficients were used to determine reproducibility. RESULTS: Inter-observer reproducibility of rCBVmax was fair with the hotspot and good with the volume method (ICC = 0.46 vs 0.65, p > 0.05). For CBVWM, it was fair with the hotspot and excellent with the volume method (0.53 vs 0.84, p < 0.05). Reproducibility of one pairwise combination of observers was significantly better for both rCBVmax and CBVWM (LCC = 0.33 vs 0.75; 0.52 vs 0.89, p < 0.05). %rCBV > 2 showed excellent inter- and intra-observer reproducibility (ICC = 0.94 and 0.91). CONCLUSION: Calculated in glioblastomas with a volume method, rCBVmax and CBVWM yielded good to excellent reproducibility but only fair with the hotspot method. Overall, the volume analysis offers a highly reproducible parameter, %rCBV > 2, that could be promising during the follow-up of such heterogeneous tumours.
PURPOSE: Despite a high variability, the hotspot method is widely used to calculate the cerebral blood volume (CBV) of glioblastomas on DSC-MRI. Our aim was to investigate inter- and intra-observer reproducibility of parameters calculated with the hotspot or a volume method and that of an original parameter assessing the fraction of pixels in the tumour volume displaying rCBV > 2: %rCBV > 2. METHODS: Twenty-seven consecutive patients with untreated glioblastoma (age: 63, women: 11) were retrospectively included. Three observers calculated the maximum tumour CBV value (rCBVmax) normalized with a reference ROI in the contralateral white matter (CBVWM) with (i) the hotspot method and (ii) with a volume method following tumour segmentation on 3D contrast-enhanced T1-WI. From this volume method, %rCBV > 2 was also assessed. After 8-12 weeks, one observer repeated all delineations. Intraclass (ICC) and Lin's (LCC) correlation coefficients were used to determine reproducibility. RESULTS: Inter-observer reproducibility of rCBVmax was fair with the hotspot and good with the volume method (ICC = 0.46 vs 0.65, p > 0.05). For CBVWM, it was fair with the hotspot and excellent with the volume method (0.53 vs 0.84, p < 0.05). Reproducibility of one pairwise combination of observers was significantly better for both rCBVmax and CBVWM (LCC = 0.33 vs 0.75; 0.52 vs 0.89, p < 0.05). %rCBV > 2 showed excellent inter- and intra-observer reproducibility (ICC = 0.94 and 0.91). CONCLUSION: Calculated in glioblastomas with a volume method, rCBVmax and CBVWM yielded good to excellent reproducibility but only fair with the hotspot method. Overall, the volume analysis offers a highly reproducible parameter, %rCBV > 2, that could be promising during the follow-up of such heterogeneous tumours.
Authors: M Iv; X Liu; J Lavezo; A J Gentles; R Ghanem; S Lummus; D E Born; S G Soltys; S Nagpal; R Thomas; L Recht; N Fischbein Journal: AJNR Am J Neuroradiol Date: 2019-09-12 Impact factor: 3.825
Authors: Meng Law; Stanley Yang; Hao Wang; James S Babb; Glyn Johnson; Soonmee Cha; Edmond A Knopp; David Zagzag Journal: AJNR Am J Neuroradiol Date: 2003 Nov-Dec Impact factor: 3.825