BACKGROUND: Mometasone-eluting stents (MES) have demonstrated improvement in short-term endoscopic outcomes and reduce short- to medium-term rescue interventions. Their effect on the local inflammatory environment, longer-term patient-reported outcomes, and radiographic severity have not been studied. METHODS: Middle meatal mucus and validated measures of disease severity were collected before and 6 to 12 months after endoscopic surgery in 52 patients with chronic rhinosinusitis with nasal polyps (CRSwNPs). Operative findings, type 2 mediator concentrations, intraoperative variables, and disease severity measures were compared between those who did and those who did not receive intraoperative frontal MES. RESULTS: A total of 52 patients with CRSwNPs were studied; 33 received frontal MES and were compared with 19 who did not. Pre-endoscopic sinus surgery (ESS) middle meatus (MM) interleukin (IL) 13 and eosinophil cationic protein (ECP) were higher in the stented group (p < 0.05), but pre-ESS clinical measures of disease severity were similar as were surgical extent and post-ESS medical management. Intraoperative eosinophilic mucin was more frequent in the stented group (58% vs 11%, p = 0.001). IL-5 (p < 0.05) and IL-13 (p < 0.001) decreased post-ESS in the stented group, but this was not observed in the nonstented group. Post-ESS IL-4 and IL-13 were higher in the nonstented vs stented group (p < 0.05 for both). CONCLUSION: Although patients who received intraoperative frontal MES had significantly higher pre-ESS MM IL-13 and ECP, patients who received frontal MES had lower concentrations of IL-4 and IL-13 than those who did not at a median of 8 months post-ESS. However, these changes did not correspond to significantly different measures of symptomatic or radiographic disease severity.
BACKGROUND: Mometasone-eluting stents (MES) have demonstrated improvement in short-term endoscopic outcomes and reduce short- to medium-term rescue interventions. Their effect on the local inflammatory environment, longer-term patient-reported outcomes, and radiographic severity have not been studied. METHODS: Middle meatal mucus and validated measures of disease severity were collected before and 6 to 12 months after endoscopic surgery in 52 patients with chronic rhinosinusitis with nasal polyps (CRSwNPs). Operative findings, type 2 mediator concentrations, intraoperative variables, and disease severity measures were compared between those who did and those who did not receive intraoperative frontal MES. RESULTS: A total of 52 patients with CRSwNPs were studied; 33 received frontal MES and were compared with 19 who did not. Pre-endoscopic sinus surgery (ESS) middle meatus (MM) interleukin (IL) 13 and eosinophil cationic protein (ECP) were higher in the stented group (p < 0.05), but pre-ESS clinical measures of disease severity were similar as were surgical extent and post-ESS medical management. Intraoperative eosinophilic mucin was more frequent in the stented group (58% vs 11%, p = 0.001). IL-5 (p < 0.05) and IL-13 (p < 0.001) decreased post-ESS in the stented group, but this was not observed in the nonstented group. Post-ESS IL-4 and IL-13 were higher in the nonstented vs stented group (p < 0.05 for both). CONCLUSION: Although patients who received intraoperative frontal MES had significantly higher pre-ESS MM IL-13 and ECP, patients who received frontal MES had lower concentrations of IL-4 and IL-13 than those who did not at a median of 8 months post-ESS. However, these changes did not correspond to significantly different measures of symptomatic or radiographic disease severity.
Authors: W J Fokkens; V J Lund; C Hopkins; P W Hellings; R Kern; S Reitsma; S Toppila-Salmi; M Bernal-Sprekelsen; J Mullol; I Alobid; W Terezinha Anselmo-Lima; C Bachert; F Baroody; C von Buchwald; A Cervin; N Cohen; J Constantinidis; L De Gabory; M Desrosiers; Z Diamant; R G Douglas; P H Gevaert; A Hafner; R J Harvey; G F Joos; L Kalogjera; A Knill; J H Kocks; B N Landis; J Limpens; S Lebeer; O Lourenco; C Meco; P M Matricardi; L O'Mahony; C M Philpott; D Ryan; R Schlosser; B Senior; T L Smith; T Teeling; P V Tomazic; D Y Wang; D Wang; L Zhang; A M Agius; C Ahlstrom-Emanuelsson; R Alabri; S Albu; S Alhabash; A Aleksic; M Aloulah; M Al-Qudah; S Alsaleh; M A Baban; T Baudoin; T Balvers; P Battaglia; J D Bedoya; A Beule; K M Bofares; I Braverman; E Brozek-Madry; B Richard; C Callejas; S Carrie; L Caulley; D Chussi; E de Corso; A Coste; U El Hadi; A Elfarouk; P H Eloy; S Farrokhi; G Felisati; M D Ferrari; R Fishchuk; W Grayson; P M Goncalves; B Grdinic; V Grgic; A W Hamizan; J V Heinichen; S Husain; T I Ping; J Ivaska; F Jakimovska; L Jovancevic; E Kakande; R Kamel; S Karpischenko; H H Kariyawasam; H Kawauchi; A Kjeldsen; L Klimek; A Krzeski; G Kopacheva Barsova; S W Kim; D Lal; J J Letort; A Lopatin; A Mahdjoubi; A Mesbahi; J Netkovski; D Nyenbue Tshipukane; A Obando-Valverde; M Okano; M Onerci; Y K Ong; R Orlandi; N Otori; K Ouennoughy; M Ozkan; A Peric; J Plzak; E Prokopakis; N Prepageran; A Psaltis; B Pugin; M Raftopulos; P Rombaux; H Riechelmann; S Sahtout; C-C Sarafoleanu; K Searyoh; C-S Rhee; J Shi; M Shkoukani; A K Shukuryan; M Sicak; D Smyth; K Sindvongs; T Soklic Kosak; P Stjarne; B Sutikno; S Steinsvag; P Tantilipikorn; S Thanaviratananich; T Tran; J Urbancic; A Valiulius; C Vasquez de Aparicio; D Vicheva; P M Virkkula; G Vicente; R Voegels; M M Wagenmann; R S Wardani; A Welge-Lussen; I Witterick; E Wright; D Zabolotniy; B Zsolt; C P Zwetsloot Journal: Rhinology Date: 2020-02-20 Impact factor: 3.681
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Authors: Jenny M Mjösberg; Sara Trifari; Natasha K Crellin; Charlotte P Peters; Cornelis M van Drunen; Berber Piet; Wytske J Fokkens; Tom Cupedo; Hergen Spits Journal: Nat Immunol Date: 2011-09-11 Impact factor: 25.606
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