Christy E Trussoni1, Steven P O'Hara1, Nicholas F LaRusso2,3. 1. Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA. 2. Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN, USA. larusso.nicholas@mayo.edu. 3. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN, 55905, USA. larusso.nicholas@mayo.edu.