| Literature DB >> 35353281 |
Ahalieyah Anantharajah1,2, Matthieu Deltombe3, Marie de Barsy3, Stephanie Evrard3, Olivier Denis3, Pierre Bogaerts3, Marie Hallin4, Véronique Yvette Miendje Deyi4, Denis Pierard5, Peggy Bruynseels6, Jerina Boelens7, Youri Glupczynski3, Te-Din Huang3.
Abstract
Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimated cause of community-acquired invasive infections in Belgium.Entities:
Keywords: Capsular serotype; Hypermucoviscosity; Hypervirulence; Klebsiella pneumoniae; Molecular epidemiology; Whole genome sequencing
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Year: 2022 PMID： 35353281 DOI： 10.1007/s10096-022-04438-z
Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267