Literature DB >> 3535236

Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein.

A Uy, V Bruss, W H Gerlich, H G Köchel, R Thomssen.   

Abstract

Hepatitis B virus (HBV) DNA contains a precore (pre-c) sequence of 29 codons with unknown function upstream of its gene for the major core protein. Its significance was studied by expression of core proteins with and without pre-c in Escherichia coli. Core protein without pre-c, P22c, assembled spontaneously to core particles and formed core antigen. It had the same size and antigenicity as core particles from infected liver. Core protein with pre-c, P25e, instead formed membrane-associated e antigen (HBeAg). The data suggest that pre-c functions as a signal peptide for the attachment of core protein P25e to cellular membranes. This hypothesis can explain the not yet understood relation between viremia and HbeAg and the protective role of anti-HBe antibody.

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Year:  1986        PMID： 3535236     DOI： 10.1016/0042-6822(86)90170-4

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  36 in total

1.  Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

Authors:  M R Brunetto; M M Giarin; F Oliveri; E Chiaberge; M Baldi; A Alfarano; A Serra; G Saracco; G Verme; H Will
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

Review 2.  Hepatology.

Authors:  P M Harrison; J Y Lau; R Williams
Journal:  Postgrad Med J       Date:  1991-08       Impact factor: 2.401

Review 3.  Viral hepatitis.

Authors:  J Y Lau; G J Alexander; A Alberti
Journal:  Gut       Date:  1991-09       Impact factor: 23.059

4.  Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22.

Authors:  C T Yeh; L H Hong; J H Ou; C M Chu; Y F Liaw
Journal:  Arch Virol       Date:  1996       Impact factor: 2.574

5.  Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection.

Authors:  T Ehata; M Omata; O Yokosuka; K Hosoda; M Ohto
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

6.  Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide.

Authors:  J H Ou; C T Yeh; T S Yen
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

7.  HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

Authors:  A Bertoletti; C Ferrari; F Fiaccadori; A Penna; R Margolskee; H J Schlicht; P Fowler; S Guilhot; F V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

8.  Characterization of the major duck hepatitis B virus core particle protein.

Authors:  J Pugh; A Zweidler; J Summers
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

9.  Effect of core protein phosphorylation by protein kinase C on encapsidation of RNA within core particles of hepatitis B virus.

Authors:  M Kann; W H Gerlich
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

10.  The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation.

Authors:  H J Schlicht; J Salfeld; H Schaller
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103
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