Junnan Geng1, Gregory Jensen1,2, Kyle Jackson1, Jefferson Pontsler1, Venkatakrishnan Rengarajan1, Yan Sun3, David Britt1, Yu Huang1. 1. Department of Biological Engineering, Utah State University, 4105 Old Main Hill, ENGR 402, Logan, UT 84322, USA. 2. Department of Chemical Engineering, Arizona State University, 501 E. Tyler Mall, Tempe, AZ 85287, USA. 3. Department of Mathematics & Statistics, Utah State University, 3900 Old Main Hill, Logan, UT 84322, USA.
Abstract
Background: Submicron particles (SMPs), as novel bionanomaterials, offer complementary benefits to their conventional nano-counterparts. Aim: To explore zinc oxide (ZnO) SMPs' bioimaging and anticancer potentials. Materials & methods: ZnO SMPs were synthesized into two shapes. Fluorescent spectrum and microscopy were studied for the bioimaging property. Wound healing and Live/Dead assays of glioblastoma cells were characterized for anticancer activities. Results: ZnO SMPs exhibited a high quantum yield (49%) with stable orange fluorescence emission. Both morphologies (most significant in the rod shape) showed tumor-selective properties in cytotoxicity, inhibition to cell migration and attenuating the cancer-upregulated genes. The tumor selectivity was attributed to particle degradation and surface properties on pH dependency. Conclusion: The authors propose that ZnO SMPs could be a promising anticancer drug with tunable, morphology-dependent properties for bioimaging and controlled release.
Background: Submicron particles (SMPs), as novel bionanomaterials, offer complementary benefits to their conventional nano-counterparts. Aim: To explore zinc oxide (ZnO) SMPs' bioimaging and anticancer potentials. Materials & methods: ZnO SMPs were synthesized into two shapes. Fluorescent spectrum and microscopy were studied for the bioimaging property. Wound healing and Live/Dead assays of glioblastoma cells were characterized for anticancer activities. Results: ZnO SMPs exhibited a high quantum yield (49%) with stable orange fluorescence emission. Both morphologies (most significant in the rod shape) showed tumor-selective properties in cytotoxicity, inhibition to cell migration and attenuating the cancer-upregulated genes. The tumor selectivity was attributed to particle degradation and surface properties on pH dependency. Conclusion: The authors propose that ZnO SMPs could be a promising anticancer drug with tunable, morphology-dependent properties for bioimaging and controlled release.
Authors: Damin Cong; Wen Zhu; Yejie Shi; Kelli B Pointer; Paul A Clark; Hongmei Shen; John S Kuo; Shaoshan Hu; Dandan Sun Journal: Carcinogenesis Date: 2014-04-09 Impact factor: 4.944
Authors: Michael Zorniak; Paul A Clark; Heather E Leeper; Matthew D Tipping; David M Francis; Kevin R Kozak; M Shahriar Salamat; John S Kuo Journal: Clin Cancer Res Date: 2012-05-15 Impact factor: 12.531