Literature DB >> 35350496

Statin Induced Autoimmune Necrotizing Myopathy (SIANM): An Alarming Adverse Event of a Familiar Medication.

Nagapratap Ganta1, Dina Alnabwani1, Veera Jayasree L Bommu1, Sharon Hechter1, Viraj Shah1,2, Pramil Cheriyath1.   

Abstract

Statins are a widely prescribed medication that lowers serum cholesterol by inhibiting the HMG-CoA reductase enzyme, a rate-limiting step in cholesterol synthesis. Myopathy is one of the well-known adverse effects of statins, mainly when prescribed with the fibrates. However, statin-induced autoimmune necrotizing myopathy (SIANM) is an infrequent and severe complication. Hence, all clinicians should be more vigilant regarding this complication and treat it early to prevent acute kidney injury (AKI).
Copyright © 2022, Ganta et al.

Entities:  

Keywords:  anti-hmg co-a reductase antibodies; hypercholesterolemia; hyperlipidemia; immune-mediated necrotizing myopathy; sianm; statin-induced autoimmune necrotizing myopathy; statin-induced myopathy

Year:  2022        PMID： 35350496      PMCID： PMC8933139          DOI： 10.7759/cureus.22273

Source DB:  PubMed          Journal:  Cureus        ISSN： 2168-8184


  12 in total

Review 1.  Statin-Associated Autoimmune Myopathy.

Authors:  Andrew L Mammen
Journal:  N Engl J Med       Date:  2016-02-18       Impact factor: 91.245

2.  Progressive myopathy with up-regulation of MHC-I associated with statin therapy.

Authors:  Merrilee Needham; Victoria Fabian; Wally Knezevic; Peter Panegyres; Paul Zilko; Frank L Mastaglia
Journal:  Neuromuscul Disord       Date:  2007-01-22       Impact factor: 4.296

Review 3.  Statin-associated immune-mediated myopathy: biology and clinical implications.

Authors:  Lisa Christopher-Stine; Pari Basharat
Journal:  Curr Opin Lipidol       Date:  2017-04       Impact factor: 4.776

Review 4.  Statin safety: a systematic review.

Authors:  Malcolm Law; Alicja R Rudnicka
Journal:  Am J Cardiol       Date:  2006-02-03       Impact factor: 2.778

Review 5.  Primary and Secondary Prevention of Acute Coronary Syndromes: The Role of the Statins.

Authors:  Evangelos Diamantis; Theodoros Troupis; Antonios Mazarakis; Giorgos Kyriakos; S Diamanti; Georgios Troupis; Panagiotis Skandalakis
Journal:  Recent Adv Cardiovasc Drug Discov       Date:  2014

6.  Immune-mediated necrotizing myopathy associated with statins.

Authors:  Phyllis Grable-Esposito; Hans D Katzberg; Steven A Greenberg; Jayashri Srinivasan; Jonathan Katz; Anthony A Amato
Journal:  Muscle Nerve       Date:  2010-02       Impact factor: 3.217

Review 7.  Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations.

Authors:  Albert Selva-O'Callaghan; Marcelo Alvarado-Cardenas; Iago Pinal-Fernández; Ernesto Trallero-Araguás; José Cesar Milisenda; María Ángeles Martínez; Ana Marín; Moisés Labrador-Horrillo; Cándido Juárez; Josep María Grau-Junyent
Journal:  Expert Rev Clin Immunol       Date:  2018-02-23       Impact factor: 4.473

Review 8.  Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.

Authors:  Erik S Stroes; Paul D Thompson; Alberto Corsini; Georgirene D Vladutiu; Frederick J Raal; Kausik K Ray; Michael Roden; Evan Stein; Lale Tokgözoğlu; Børge G Nordestgaard; Eric Bruckert; Guy De Backer; Ronald M Krauss; Ulrich Laufs; Raul D Santos; Robert A Hegele; G Kees Hovingh; Lawrence A Leiter; Francois Mach; Winfried März; Connie B Newman; Olov Wiklund; Terry A Jacobson; Alberico L Catapano; M John Chapman; Henry N Ginsberg
Journal:  Eur Heart J       Date:  2015-02-18       Impact factor: 29.983

9.  Statin-induced necrotizing autoimmune myopathy: an extremely rare adverse effect from statin use.

Authors:  Priyadarshani Sharma; Bidhya Timilsina; Janak Adhikari; Prem Parajuli; Rashmi Dhital; Niranjan Tachamo
Journal:  J Community Hosp Intern Med Perspect       Date:  2019-12-14

10.  Statin-Induced Autoimmune Necrotizing Myopathy.

Authors:  Sahani Jayatilaka; Kunal Desai; Swarup Rijal; Debra Zimmerman
Journal:  J Prim Care Community Health       Date:  2021 Jan-Dec
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