| Literature DB >> 35350193 |
Guilherme R F Campos1, Nathalie Bonatti Franco Almeida2, Priscilla Soares Filgueiras2, Camila Amormino Corsini2, Sarah Vieira Contin Gomes2, Daniel Alvim Pena de Miranda2, Jéssica Vieira de Assis2, Thaís Bárbara de Souza Silva3, Pedro Augusto Alves3, Gabriel da Rocha Fernandes2, Jaquelline Germano de Oliveira4, Paula Rahal5, Rafaella Fortini Grenfelle Queiroz2, Maurício L Nogueira6.
Abstract
The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times, indicating a positive impact of this vaccine combination in the serological immune response.Entities:
Year: 2022 PMID： 35350193 PMCID： PMC8963699 DOI： 10.1101/2022.03.24.22272904
Source DB: PubMed Journal: medRxiv