Literature DB >> 353493

Ability of chloramphenicol to suppress phenotypically some bacterial mutations.

V Kuhrová, B Koukalová, J Reich.   

Abstract

Chloramphenicol (CLP) at slightly inhibitory concentrations (3-5 microgram/ml) suppresses the inhibition of DNA synthesis and cell division caused by the temperature sensitive mutation dnaE486 at the nonpermissive temperature. Some other mutations can also be phenotypically suppressed by CLP. A similar effect is shown by chlortetracycline. Phenotypic suppression is caused by both these drugs in different cases than by streptomycin.

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Year:  1978        PMID： 353493     DOI： 10.1007/bf00332975

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  16 in total

1.  Time, temperature, and protein synthesis: a study of ultraviolet-induced mutation in bacteria.

Authors:  E M WITKIN
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1956

2.  The chloramphenicol receptor site in Escherichia coli in vivo affinity labeling by monoidoamphenicol.

Authors:  O Pongs; W Messer
Journal:  J Mol Biol       Date:  1976-02-25       Impact factor: 5.469

3.  Isolation and characterization of thermosensitive Escherichia coli mutants defective in deoxyribonucleic acid replication.

Authors:  J A Wechsler; V Nüsslein; B Otto; A Klein; F Bonhoeffer; R Herrmann; L Gloger; H Schaller
Journal:  J Bacteriol       Date:  1973-03       Impact factor: 3.490

4.  Escherichia coli mutants with temperature-sensitive synthesis of DNA.

Authors:  P L Carl
Journal:  Mol Gen Genet       Date:  1970

5.  Classification of aminotransferase (C gene) mutants in the histidine operon.

Authors:  H J Whitfield; R G Martin; B N Ames
Journal:  J Mol Biol       Date:  1966-11-14       Impact factor: 5.469

6.  Induction of error-prone repair as a consequence of DNA ligase deficiency in Escherichia coli.

Authors:  L S Morse; C Pauling
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

7.  Simple bacterial systems for detecting mutagenic agents.

Authors:  B A Bridges
Journal:  Lab Pract       Date:  1972-06

8.  Function of DNA polymerase 3 in DNA replication.

Authors:  V Nüsslein; B Otto; F Bonhoeffer; H Schaller
Journal:  Nat New Biol       Date:  1971-12-29

Review 9.  Inhibitors of ribosome functions.

Authors:  S Pestka
Journal:  Annu Rev Microbiol       Date:  1971       Impact factor: 15.500

10.  Escherichia coli mutants temperature-sensitive for DNA synthesis.

Authors:  J A Wechsler; J D Gross
Journal:  Mol Gen Genet       Date:  1971
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