Kristina M Jordahl1,2, Kathleen E Malone2, Michelle L Baglia2, Meghan R Flanagan2,3, Mei-Tzu C Tang2, Peggy L Porter2,4, Christopher I Li5. 1. Department of Epidemiology, University of Washington, Seattle, WA, USA. 2. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 3. Department of Surgery, University of Washington, Seattle, WA, USA. 4. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. 5. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. cili@fredhutch.org.
Abstract
PURPOSE: Alcohol is an established risk factor for invasive breast cancer, and women with a prior ductal carcinoma in situ diagnosis are at higher risk of invasive breast cancer than the general population. However, for women with a prior ductal carcinoma in situ diagnosis, few studies have evaluated the association between alcohol and smoking and risk of subsequent invasive breast cancer. METHODS: Utilizing a population-based case-control design nested among women diagnosed with a ductal carcinoma in situ between 1995 and 2013, we compared 243 cases diagnosed with a subsequent invasive breast cancer and 423 individually matched controls never diagnosed with a subsequent breast cancer. RESULTS: Compared with never to occasional drinkers, drinkers consuming at least 7 alcoholic drinks per week on average at ductal carcinoma in situ diagnosis had a higher risk of invasive breast cancer that was borderline significant (OR 1.79, 95% CI 1.01-3.17, P value = 0.04). Smoking was not significantly associated with risk of developing an invasive breast cancer after adjustment for alcohol consumption. CONCLUSIONS: These findings suggest that consuming at least one alcoholic drink per day on average is positively associated with invasive breast cancer for women with a prior ductal carcinoma in situ diagnosis. If confirmed, modulating alcohol consumption could be one strategy for women with a history of ductal carcinoma in situ to impact their risk of invasive breast cancer.
PURPOSE: Alcohol is an established risk factor for invasive breast cancer, and women with a prior ductal carcinoma in situ diagnosis are at higher risk of invasive breast cancer than the general population. However, for women with a prior ductal carcinoma in situ diagnosis, few studies have evaluated the association between alcohol and smoking and risk of subsequent invasive breast cancer. METHODS: Utilizing a population-based case-control design nested among women diagnosed with a ductal carcinoma in situ between 1995 and 2013, we compared 243 cases diagnosed with a subsequent invasive breast cancer and 423 individually matched controls never diagnosed with a subsequent breast cancer. RESULTS: Compared with never to occasional drinkers, drinkers consuming at least 7 alcoholic drinks per week on average at ductal carcinoma in situ diagnosis had a higher risk of invasive breast cancer that was borderline significant (OR 1.79, 95% CI 1.01-3.17, P value = 0.04). Smoking was not significantly associated with risk of developing an invasive breast cancer after adjustment for alcohol consumption. CONCLUSIONS: These findings suggest that consuming at least one alcoholic drink per day on average is positively associated with invasive breast cancer for women with a prior ductal carcinoma in situ diagnosis. If confirmed, modulating alcohol consumption could be one strategy for women with a history of ductal carcinoma in situ to impact their risk of invasive breast cancer.
Authors: Mia M Gaudet; Brian D Carter; Louise A Brinton; Roni T Falk; Inger T Gram; Juhua Luo; Roger L Milne; Sarah J Nyante; Elisabete Weiderpass; Laura E Beane Freeman; Dale P Sandler; Kim Robien; Kristin E Anderson; Graham G Giles; Wendy Y Chen; Diane Feskanich; Tonje Braaten; Claudine Isaacs; Lesley M Butler; Woon-Puay Koh; Alicja Wolk; Hans-Olov Adami; Emily White; Karen L Margolis; Michael J Thun; Susan M Gapstur Journal: Int J Epidemiol Date: 2017-06-01 Impact factor: 7.196