| Literature DB >> 35347148 |
S Ghazanfar1,2, N Lamichane3,4, E Havula5,6,7, D Francis1, K Hasygar3,4, Y Liu3,4, L A Alton8, J Johnstone8, E J Needham1,9, T Pulpitel1, T Clark1, H N Niranjan1, V Shang1, V Tong1, N Jiwnani1, G Audia1, A N Alves8, L Sylow10,11, C Mirth8, G G Neely1,9, J Yang1,12, V Hietakangas3,4, S J Simpson1,9, A M Senior13,14,15.
Abstract
Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.Entities:
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Year: 2022 PMID： 35347148 PMCID： PMC8960806 DOI： 10.1038/s41467-022-29183-x
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 17.694