Literature DB >> 3534636

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography.

E S Corp, S C Woods, D Porte, D M Dorsa, D P Figlewicz, D G Baskin.   

Abstract

In vitro autoradiography and computer video densitometry were used to localize and quantify binding of 125I-insulin in the hypothalamus of the rat brain. Highest specific binding was found in the arcuate, dorsomedial, suprachiasmatic, paraventricular and periventricular regions. Significantly lower binding was present in the ventromedial nucleus and median eminence. The results are consistent with the hypothesis that insulin modulates the neural regulation of feeding by acting at sites in the hypothalamus.

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Year:  1986        PMID: 3534636     DOI: 10.1016/0304-3940(86)90430-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  20 in total

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