[Pharmacokinetics of anti-hypertensive drugs in renal failure].

Anti-hypertensive drugs which are mainly eliminated by the kidney can accumulate in renal failure. Posology of hydrosoluble beta-blockers, converting enzyme inhibitors and central anti-hypertensive drugs should therefore be reduced. Anti-hypertensive drugs whose metabolism is predominantly or exclusively hepatic, such as liposoluble beta-blockers, calcium antagonists and prazosin, can be used at usual posologies. At end-stage renal failure posology of diuretics may have to be increased in order to attain a pharmacodynamic effect.