Synthesis of a Bioactive Composition of Chitosan-Selenium Nanoparticles.

A biologically active composition of chitosan-selenium nanoparticles has been developed. Selenium nanoparticles are characterized by a clear bimodal size distribution: 2-3 and ~37 nm. The main active centers of complexation with nanoparticles are the amino and hydroxyl groups of chitosan. In experiments on culturing fibroblasts of the hTERT BJ-5ta cell line on sample films, high biocompatibility of the composition was shown. It was shown that the composition of chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals. This opens up prospects for the use of this complex in the composition of antioxidant and adaptogenic drugs. © Pleiades Publishing, Inc. 2022, ISSN 0003-6838, Applied Biochemistry and Microbiology, 2022, Vol. 58, No. 2, pp. 126–131. © Pleiades Publishing, Inc., 2022.Russian Text