Maternal PARK7 (DJ-1) levels and the preterm premature rupture of membranes: Correspondence.

Dear Editor,

We would like to share ideas on the publication “The association between increased maternal Parkinson disease protein 7 (PARK7) (DJ-1) levels and the occurrence of preterm premature rupture of membranes (PPROM) - A randomized prospective study(.” Turhan and Tatar( concluded that “PARK7 is overexpressed in PPROM patients. Due to its anti-inflammatory and antioxidant properties, PARK7 may be a novel marker in better understanding the pathophysiology and prediction of the prognosis PPROM. Further large-scale studies are needed(.” We agree that PARK7 might be useful for management of PPROM. However, as Turhan and Tatar( noted, further studies are required. Other obstetric complication such as pre-eclampsia also affect level of DJ-1(. Also, quality control in analysis of the DJ-1 is necessary. In clinical chemistry, different centrifugation condition can significantly affect measurement of DJ-19(. These factors are important considerations in using maternal DJ-1 as biomarker.