| Literature DB >> 3534198 |
M Santosham, B A Burns, R Reid, G W Letson, B Duncan, J A Powlesland, S Foster, S Garrett, L Croll, W Nyunt Nyunt.
Abstract
We evaluated the safety and efficacy of a glycine-based orally administered rehydration solution by comparing it with a standard oral rehydration solution (ORS) without glycine in a randomized double-blind trial in United States infants (age less than 15 months) given treatment for acute gastroenteritis as inpatients or outpatients. The response to therapy (stool volume and duration of illness) was similar in the two groups, except that in four (13%) of 31 hospitalized infants receiving glycine-ORS hypernatremia developed, (one had symptoms) compared with none of 35 receiving ORS (P less than 0.04). Among the 77 outpatients there were no differences between the groups. This study demonstrates that glycine-ORS did not provide any therapeutic advantage over standard ORS, and hypernatremia developed in some patients receiving glycine-ORS. We suggest that caution be used with this type of solution until further safety studies have been done.Entities:
Keywords: Americas; Biology; Data Analysis; Demographic Factors; Developed Countries; Diarrhea; Diarrhea, Infantile; Diseases; Double-blind Studies; Electrolyte Balance; Examinations And Diagnoses; Homeostasis; Laboratory Examinations And Diagnoses; North America; Northern America; Oral Rehydration--administraction and dosage; Physiology; Population; Population Characteristics; Research Methodology; Studies; Treatment; United States
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Year: 1986 PMID： 3534198 DOI： 10.1016/s0022-3476(86)80696-5
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406