Literature DB >> 35341941

Identifying targets to prevent aminoglycoside ototoxicity.

Jinkyung Kim1, Sriram Hemachandran1, Alan G Cheng2, Anthony J Ricci3.   

Abstract

Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.
Copyright © 2022 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aminoglycoside; Cochlea; Hair cell; Ototoxicity

Mesh：

Substances：

Year:  2022        PMID： 35341941      PMCID： PMC9177639          DOI： 10.1016/j.mcn.2022.103722

Source DB:  PubMed          Journal:  Mol Cell Neurosci        ISSN： 1044-7431            Impact factor:   4.626


  50 in total

1.  Ototoxicity: the hidden menace.

Authors:  Manisha Bisht; S S Bist
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  2011-02-23

Review 2.  Aminoglycoside toxicity in neonates: something to worry about?

Authors:  Alison Kent; Mark A Turner; Mike Sharland; Paul T Heath
Journal:  Expert Rev Anti Infect Ther       Date:  2014-01-21       Impact factor: 5.091

3.  Inhibition of ribosomal translocation by aminoglycoside antibiotics.

Authors:  M J Cabañas; D Vázquez; J Modolell
Journal:  Biochem Biophys Res Commun       Date:  1978-08-14       Impact factor: 3.575

4.  Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.

Authors:  Yoshiyuki Kawashima; Gwenaëlle S G Géléoc; Kiyoto Kurima; Valentina Labay; Andrea Lelli; Yukako Asai; Tomoko Makishima; Doris K Wu; Charles C Della Santina; Jeffrey R Holt; Andrew J Griffith
Journal:  J Clin Invest       Date:  2011-11-21       Impact factor: 14.808

5.  Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.

Authors:  Yuji Karashima; Jean Prenen; Karel Talavera; Annelies Janssens; Thomas Voets; Bernd Nilius
Journal:  Biophys J       Date:  2010-03-03       Impact factor: 4.033

6.  Properties of the inner pore region of TRPV1 channels revealed by block with quaternary ammoniums.

Authors:  Andrés Jara-Oseguera; Itzel Llorente; Tamara Rosenbaum; León D Islas
Journal:  J Gen Physiol       Date:  2008-11       Impact factor: 4.086

7.  In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics.

Authors:  S A Kabins; C Nathan; S Cohen
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

8.  Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria.

Authors:  L E Bryan; H M Van Den Elzen
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

9.  Differences in Ototoxicity across Species.

Authors:  Brian W Blakley; Jordan Hochman; Mark Wellman; Adrian Gooi; Abdulmohsen E Hussain
Journal:  J Otolaryngol Head Neck Surg       Date:  2008-10
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