Literature DB >> 3534144

Prospects for the therapeutic use of human monoclonal antibodies.

J W Larrick, J M Bourla.   

Abstract

Despite much recent progress, human monoclonal antibodies (HuMAbs) are currently more difficult to generate than conventional rodent monoclonals. Clinical trials using rodent monoclonals suggest that they can be given safely, but that the human antimouse immune response can limit their efficacy. We review the human monoclonals that have been generated to date, and explore the clinical uses that will be made of these reagents in the near future.

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Year:  1986        PMID： 3534144

Source DB:  PubMed          Journal:  J Biol Response Mod        ISSN： 0732-6580


  7 in total

1.  Monoclonal antibodies.

Authors:  S P Cole
Journal:  Can Fam Physician       Date:  1987-02       Impact factor: 3.275

2.  Pharmacokinetic studies of radiolabelled rat monoclonal antibodies recognising syngeneic sarcoma antigens. I. Comparison of IgG subclasses.

Authors:  S A Eccles; H P Purvies; J M Styles; S M Hobbs; C J Dean
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

3.  Human monoclonal antibodies produced by primary in vitro immunization of peripheral blood lymphocytes.

Authors:  C A Borrebaeck; L Danielsson; S A Möller
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Generation of human monoclonal antibodies by transformation of lymphoblastoid B cells with ras oncogene.

Authors:  S Shammah; T L Mantovani; R Dalla-Favera; P Casali
Journal:  J Immunol Methods       Date:  1993-03-15       Impact factor: 2.303

Review 5.  The production and application of non-rodent monoclonal antibodies in veterinary science.

Authors:  D J Groves; E M Tucker
Journal:  Vet Immunol Immunopathol       Date:  1989-11-30       Impact factor: 2.046

6.  Heterohybridomas that secrete high levels of pseudomonas-specific therapeutic human monoclonal antibodies: their generation and large scale growth in an automated hollow fiber cell culture system.

Authors:  M C Gammon; M H Banas; L E Boccumini; N H Sigal; H J Zweerink
Journal:  Cytotechnology       Date:  1990-01       Impact factor: 2.058

Review 7.  Human monoclonal antibodies from transgenic mice.

Authors:  N Lonberg
Journal:  Handb Exp Pharmacol       Date:  2008
  7 in total

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