Literature DB >> 35341316

Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum.

Rui Kano1,2, Utako Kimura3, Hiromitsu Noguchi4,5, Masataro Hiruma5.   

Abstract

The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (SQLE) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole resistance.

Entities:  

Keywords:  Trichophyton rubrum; azole; deletion mutation; dermatophytes; dermatophytoses; onychomycosis; squalene epoxidase; terbinafine

Mesh：

Substances：

Year:  2022        PMID： 35341316      PMCID： PMC9017306          DOI： 10.1128/aac.02393-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  11 in total

Review 1.  Onychomycosis: Clinical overview and diagnosis.

Authors:  Shari R Lipner; Richard K Scher
Journal:  J Am Acad Dermatol       Date:  2018-06-28       Impact factor: 11.527

2.  ATP-binding Cassette (ABC) Transporter Proteins in Highly Terbinafine-resistant Strains of Trichophyton indotineae (Former Species Name: Trichophyton interdigitale).

Authors:  Rui Kano
Journal:  Med Mycol J       Date:  2021

3.  In vitro activities of antifungal agents against clinical isolates of dermatophytes from animals.

Authors:  Sayuri Itoi; Rui Kano; Atsuhiko Hasegawa; Hiroshi Kamata
Journal:  J Vet Med Sci       Date:  2012-04-02       Impact factor: 1.267

4.  Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine.

Authors:  Colin S Osborne; Ingrid Leitner; Bertrand Favre; Neil S Ryder
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

5.  Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene.

Authors:  Tsuyoshi Yamada; Mari Maeda; Mohamed Mahdi Alshahni; Reiko Tanaka; Takashi Yaguchi; Olympia Bontems; Karine Salamin; Marina Fratti; Michel Monod
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

6.  Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes.

Authors:  Maíra Pompeu Martins; Ana Carolina Capovilla Franceschini; Tiago Rinaldi Jacob; Antonio Rossi; Nilce Maria Martinez-Rossi
Journal:  J Med Microbiol       Date:  2016-04-26       Impact factor: 2.472

7.  Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection.

Authors:  Ditte M L Saunte; Rasmus K Hare; Karin M Jørgensen; René Jørgensen; Mette Deleuran; Claus O Zachariae; Simon F Thomsen; Lars Bjørnskov-Halkier; Kristian Kofoed; Maiken C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

Review 8.  Recent Findings in Onychomycosis and Their Application for Appropriate Treatment.

Authors:  Michel Monod; Bruno Méhul
Journal:  J Fungi (Basel)       Date:  2019-02-22

9.  Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3.

Authors:  Michel Monod; Marc Feuermann; Karine Salamin; Marina Fratti; Maya Makino; Mohamed Mahdi Alshahni; Koichi Makimura; Tsuyoshi Yamada
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191
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