Shortness of Breath on Day 1 After Surgery Alerting the Presence of Early Respiratory Complications After Surgery in Lung Cancer Patients.

Purpose: Patient-reported outcome (PRO)-based symptom assessment with a threshold can facilitate the early alert of adverse events. The purpose of this study was to determine whether shortness of breath (SOB) on postoperative day 1 (POD1) can inform postoperative pulmonary complications (PPCs) for patients after lung cancer (LC) surgery.
Methods: Data were extracted from a prospective cohort study of patients with LC surgery. Symptoms were assessed by the MD Anderson Symptom Inventory-lung cancer module (MDASI-LC) before and daily after surgery. Types and grades of complications during hospitalization were recorded. SOB and other symptoms were tested for a possible association with PPCs by logistic regression models. Optimal cutpoints of SOB were derived, using the presence of PPCs as an anchor.
Results: Among 401 patients with complete POD1 MDASI-LC and records on postoperative complications, 46 (11.5%) patients reported Clavien-Dindo grade II-IV PPCs. Logistic regression revealed that higher SOB score on POD1 (odds ratio [OR]=1.13, 95% CI=1.01-1.27), male (OR=2.86, 95% CI=1.32-6.23), open surgery (OR=3.03, 95% CI=1.49-6.14), and lower forced expiratory volume in one second (OR=1.78, 95% CI=1.66-2.96) were significantly associated with PPCs. The optimal cutpoint was 6 (on a 0-10 scale) for SOB. Patients reporting SOB < 6 on POD1 had shorter postoperative length of stay than those reporting 6 or greater SOB (median, 6 vs 7, P =0.007).
Conclusion: SOB on POD1 can inform the onset of PPCs in patients after lung cancer surgery. PRO-based symptom assessment with a clinically meaningful threshold could alert clinicians for the early management of PPCs.

Introduction

Postoperative pulmonary complications (PPCs) are one of the major problems in patients following lung cancer (LC) surgery.1,2 It has been reported that the incidence of PPCs reaches 14% to 40% after LC resection, which is greater than that in other major procedures.3 PPCs typically occurred within the first week after surgery and nearly 25% of the postoperative deaths that occur in this time are related to PPCs.4,5 In addition, PPCs can result in delayed recovery, greater Medical expense,6 and obvious respiratory symptom burden, such as dyspnea and cough, for patients with LC.7 Thus, accurate monitoring, alerting, and preparing an appropriate plan for PPCs as early as possible are needed to reduce patient mortality and morbidity during the perioperative period.

After LC surgery, patients commonly suffer from numerous symptoms, such as pain, coughing, dyspnea, and fatigue.8 Including heterogeneous surgery types, a previous study associated an increased risk of respiratory complications such as atelectasis and pulmonary infections with postoperative pain.9 The positive association between early postoperative pain and 30-day postoperative complications demonstrated that symptom monitoring in the early recovery period (ie, the first several days after surgery) can alert negative events related to the procedure and then promote postoperative recovery. Unfortunately, for patients undergoing cancer surgery, pain is a general symptom induced by all kinds of surgery,10 and complications vary from procedures.11 For patients with LC surgery, there is a need for PPCs-specified symptoms to be clearly defined for early intervention.

Dyspnea is a highly frequent and disruptive symptom posttreatment in LC patients, with a prevalence up to 90% in advanced disease.12 Different from other symptoms, the severity of dyspnea worsens partly because of a loss of 10–15% of lung function after surgery,13,14 and it can substantially add to the onset of fatigue,15 which has been shown to have a strong correlation with quality of life (QOL) and finally to increase the risk of PPCs.16 Fagundes et al reported that the occurrence of dyspnea was associated with postoperative tissue injury and medications induced metabolic stress response.17 The degree of dyspnea was commonly measured by the modified Medical Research Council (mMRC) dyspnea scale and transition dyspnea Index (TDI) in chronic obstructive pulmonary disease.18,19 American Thoracic Society defines dyspnea as a subjective experience of breathing discomfort and can be accurately obtained from a patient report on the severity and frequency of “shortness of breath” (SOB).20,21

Of note, the patient-reported outcome (PRO) has been widely used for surgical outcome reporting22 and can provide clinicians precise information on patients’ experience with aggressive cancer treatments.23 Recently, several investigators have demonstrated that using a web-based symptom monitoring system can reduce symptom burden and improve the overall survival of patients with advanced cancer.24,25 This process is done through a mechanism that using the weekly PRO assessment of index symptoms with an alert threshold can inform the clinician of the early onset of adverse events. Therefore, there is a great possibility of using PRO-based symptom monitoring to generate alerts to inform clinicians about the potential risk of PPCs after lung resection.

However, despite increasing awareness of the serious negative effects on SOB, it is still an undetected symptom and should be accurately assessed, recorded, and related to postoperative complications.26 Moreover, using PRO-based symptoms to alert severe postoperative outcomes early is hampered by the lack of data on how those symptoms change over the course of recovering from LC surgery and at what level of symptom severity the clinician should be informed for further clinical actions.

With the availability of prospectively collected symptom and PPCs data during hospitalization after thoracic surgery, we conducted an analysis with longitudinal PRO-based symptom assessment in patients with LC surgery. The objectives of the current analysis were (1) to describe the trajectory of SOB based on a group-based trajectory model (GBTM) from preoperation to one week after surgery; (2) to determine whether SOB on postoperative day 1 (POD1) can inform PPCs after thoracic surgery; (3) to establish cutpoint of SOB, anchored by the presence of PPCs; and (4) to demonstrate the sensitivity of SOB cutpoints in differentiating clinical outcomes, such as postoperative length of stay (PLOS) and functional status.

Materials and Methods

Study Design and Patients

Patients for this study were from a prospective observational cohort study (NCT03341377) investigating the perioperative symptom burden for lung cancer patients from Nov, 2017 to Jan, 2020 in 6 tertiary hospitals in China. The study protocol was published in 2019.27 Eligible patients of this study were at least over 18 years old, can understand the study requirements, and participate in the study (Figure 1). Patients were not included in this analysis if (1) the postoperative pathological type was benign pulmonary disease, (2) the 16 symptom severity items or 6 symptom interference items of the MDASI-LC were missing, and (3) complications of subcutaneous pneumatosis or postoperative blood transfusion occurred during hospitalization. The study was approved by the Ethics Committee of each hospital. Written informed consent was obtained from all participating patients.

Figure 1

Study flow diagram for analytical sample.

Measurements

Symptoms were assessed using the MD Anderson Symptom Inventory-lung cancer module (MDASI-LC),28 a brief, validated and lung cancer-specific PRO instrument. The MDASI-LC consists of SOB and other 12 common cancer-related symptoms and 6 items of symptom interference with daily function. The MDASI-LC also assesses 3 symptoms (coughing, constipation and sore throat) specific to lung cancer. Each item is rated on a 0–10 numerical scale, with 0 being “not present” or “did not interfere” and 10 presenting “as bad as you can imagine” or “interfered completely.” The recall period was 24 hours. MDASI-LC was administered within 3 days prior to the operation, daily after surgery (up to 14 days), and weekly after discharge until 4 weeks or the start of postoperative adjuvant treatment. Since the majority of PPCs were diagnosed within 1 week after surgery,4 data from preoperation to one week after surgery were used in this analysis. Other data, such as demographic characteristics, preoperative characteristics, surgery, types and grades of complications during hospitalization of all patients, were collected and recorded in the REDCap database.29 The surgical resection types including lobectomy, sublobectomy and others. Lobectomy was a procedure with the entire lobe of lung resection, requiring dissection and ligation of vascular and bronchial structure; Sublobectomy was consisted of segmentectomy and wedge resection and regarded as the resection extent less than a lobe either requiring dissection of sectional vascular and bronchus or not.30 Others were included bilobectomy, sleeve lobectomy, and sublobectomy plus sublobectomy or lobectomy.31

Postoperative Pulmonary Complications

We used the Clavien-Dindo classification (CDC)32 criteria of surgical complications to score the severity of PPCs in 5 grades. PPCs were defined as the occurrence of one or more of the following complications with Clavien-Dindo grade ≥ II from the day of surgery to hospital discharge:33–38 (1) pneumonia, associated with 3 of the 4 following criteria or one of the first three and the fourth criterion: 1) fever with temperature >38.0°C after 72 hours postoperatively, 2) leukocytosis with white blood cell count > (12–15) × 109/L or returned to normal value but then increased again > 10 × 109/L, 3) lung consolidation or increasing patchy opacity on chest imaging, and 4) purulent sputum or positive sputum culture; (2) prolonged air leak, defined as persistent air leak from the drainage tube for more than 7 days after surgery and bronchopleural fistula were excluded; (3) postoperative pneumothorax, the accumulation of effusion or air in the pleural space of the operative side after surgery, with symptoms such as dyspnea and requiring treatments such as reinsertion; (4) pneumothorax, the accumulation of air in the pleural space of the non-operative side during or after surgery, with the lungs were compressed by more than 30% and requiring treatments; (5) bronchopleural fistula, the abnormal passage between the bronchus and the pleura confirmed by bronchoscope; (6) respiratory failure, postoperative PaO2 <60mmHg on room air, a ratio of PaO2 to inspired oxygen fraction <300 mmHg, or pulse oximetry <90% and requiring oxygen therapy.

Statistical Methods

Descriptive statistics were used to summarize demographic and clinical characteristics. Normally distributed continuous variables are expressed as the mean (± standard deviation, SD), and skewed continuous variables are expressed as the median (interquartile range, IQR 25th–75th percentile), while the differences were compared with the t-test and the Wilcoxon rank sum test. Categorical variables are expressed as a number and percentage (%) and were analyzed using the χ2 test or Fisher’s exact test for categorical variables where the numbers per cell were 5 or less.

Group-based trajectory modeling (GBTM) was used to identify patient subgroups with distinct symptom trajectories over the course of recovering from thoracic surgery, with the SOB score considered the dependent variable. The SAS macro PROC TRAJ was used to estimate trajectories on the basis of data collected at 8 time points from before surgery to postoperative day 7.39 We generated a two-group model with the prior of simplicity and clinical interpretability, representing either a high or low symptom burden over time during the 7-day study because the two-group model could identify subgroups of the symptom burden in patients who received aggressive cancer treatment.40

Factors, such as sex (male vs female), history of smoking (smoking vs never smoking), and approach of operations (Open vs VATs), age (> 55 vs ≤ 55) and forced expiratory volume in one second (FEV1), were tested using univariate analysis with the presence of grade II or greater PPCs as the dependent variable. Those variables with P values less than or equal to 0.05 were entered into the multivariate logistic analyses to determine the risk factors for PPCs.

To establish clinically meaningful thresholds of symptoms to inform the onset of major complications, we used a single dependent variable of PPCs as the anchor to drive symptom interference cutpoints. Binary logistic analysis was used to identify the optimal cutpoint for categorizing symptom scales into 2 levels. We examined 9 different sets of cutpoints (CPs) (CP1, CP2, CP3. CP4, CP5, CP6, CP7, CP8, and CP9). Each group was considered a new variable and used as an independent variable to simulate a logistic regression model with the occurrence of PPCs as the dependent variable. Using the minimum P-value approach, the cutpoints that produced the maximum Wald chi-squared statistic would be selected as the optimal cutpoints for each symptom scale.41 Bootstrap resampling with 2000 samples was used to check that the choice of optimal cutpoints was robust.

To validate the optimal cutpoint, we assessed how the derived symptom categories differed in functional interference and postoperative length of hospital stay (PLOS). We used mixed-effects models to compare the MDASI-LC symptom interference scores from pre-operation to 7 days after surgery during hospitalization in patients with different SOB symptom levels by the cutpoints. In these models, the score of symptom interference (continuous variable) was considered the dependent variable; the independent variables were the time and the interaction between time and SOB symptom severity. The maximum likelihood estimation method was used to calculate the fixed effects of all dependent variables and random effects for the intercept and time.

All statistical analyses were conducted using JMP software version 13.0 (SAS Institute Inc., Cary, NC, USA), and a two-sided p-value < 0.05 was considered significant.

Results

Patient Characteristics

A total of 401 patients with complete POD1 MDASI-LC and records on postoperative complications were included and analyzed in this study. Baseline demographic and clinical features are summarized in Table 1. The average age of the patients was 56.1 ± 10.4 years, and 47.9% (n=192) were women. Of patients included in the study, 252 (62.8%) were never smokers, 106 (26.4%) were current smokers, and 43 (10.7%) were former smokers. More than half of the patients were staged with TNM I/II (63.3%). The surgical approach consisted of open surgery (19.5%) and VATS (80.6%). Median [IQR] days of PLOS was 7 [5-8] days.

Table 1

Demographics and Clinical Characteristics

Demographic or Clinical Characteristics	Total = 401
Age (years), mean (SD)	56.2 (10.4)
FEV1 (L), median (IQR)	2.3 (1.9–2.8)
MVV (L/min), median (IQR)	93.2 (75.3–111.4)
DLCO SB (mmol/min/kPa), median (IQR)	7.3 (5.9–8.7)
Postoperative length of stay in hospital (days), median (IQR)	7.0 (5.0–8.0)
Operation time, median (IQR)	134.0 (105.0–170.0)
Shortness of breath score on POD1, median (IQR)	4.0 (1.0–6.0)
Age
≤55	192 (47.9%)
>55	209 (52.1%)
Gender
Male	209 (52.1%)
Female	192 (47.9%)
Smoking history
Never smoker	252 (62.8%)
Current smoker	106 (26.4%)
Former smoker	43 (10.7%)
ASA classification
I	179 (44.6%)
>I	222 (55.4%)
CCI score
0–1	232 (57.9%)
> 1	169 (42.1%)
Postoperative pathologic TNM stage
0~I	254 (63.3%)
II~IV	147 (36.7%)
Chest tube number
One	257 (64.1%)
Two	144 (35.9%)
Surgical approach
Open surgery	78 (19.4%)
VATS	323 (80.6%)
Extent of surgery
Lobectomy	256 (63.8%)
Sublobectomy	62 (15.5%)
Others*	83 (20.7%)

Notes: Data are expressed as median (IQR) or n (%). *Others included bilobectomy, sleeve lobectomy, and sublobectomy plus sublobectomy or lobectomy.

Abbreviations: SD, standard deviation; ASA, American Society of Anesthesiologists; CCI, Charlson Comorbidity Index; FEV1, forced expiratory volume in one second; MVV, maximal ventilatory volume; DLCO SB, carbon monoxide diffusing capacity single-breath method; TNM, tumor node metastasis; VATS, video-assisted thoracoscopic surgery; IQR, 25th–75th percentile.

A total of 11.5% (n=46) of patients reported grade II–IV PPCs during hospitalization after surgery, and 18 (4.5%) patients reported two or more types of PPCs (). Total 55 PPCs events with Clavien-Dindo grade ≥ II were reported while postoperative pneumonia (5.7%) was the most frequent PPCs, followed by prolonged air leak (>7d) (5.5%), postoperative pneumothorax (1.7%), pneumothorax (0.2%), and bronchopleural fistula (0.5%).

Risk Factors for PPCs

The univariate analyses revealed that male, approach of operations, FEV1, and SOB on POD1 were significantly associated with PPCs (all P < 0.05). Multivariate logistic regression model identified that variables significantly associated with PPCs, including male (odds ratio [OR]: 2.86, 95% CI: 1.32–6.23; P=0.008); open surgery (OR: 3.03; 95% CI: 1.49–6.14; P=0.002); lower FEV1 (OR: 1.78; 95% CI: 1.66–2.96; P=0.025); and SOB on POD1 (OR: 1.13, 95% CI: 1.01–1.27; P=0.034) (Table 2).

Table 2

Multivariate Logistic Regression Analysis of Risk Factors for PPCs During Hospitalization After Surgery

Relative Factors	PPCs (n=46)	Non-PPCs (n=355)	Multivariate Analysis
			Odds Ratio	95% CI	P
Sex*
Male	34 (16.3)	175 (83.7)	2.86	1.32–6.23	0.008
Female	12 (6.3)	180 (93.7)	Ref.
Surgery*
Open surgery	21 (26.9)	57 (73.1)	3.03	1.49–6.14	0.002
VATS	25 (7.7)	298 (92.3)	Ref.
FEV1**	2.16 (1.6–2.8)	2.34 (2.0–2.8)	1.78	1.66–2.96	0.025
Shortness of breath on POD1**	5 (3–7)	3 (1–5)	1.13	1.01–1.27	0.034

Notes: Statistically significant values are given in bold (P< 0.05); *N (%); **Median (IQR).

Abbreviations: FEV1, forced expiratory volume in one second; CI, confidence interval.

Postoperative Symptom Trajectory by GBTM Selection and Evaluation of SOB

According to the results of GBTM, we defined the two-group symptom trajectories as patients-reported persistently with lower severity on SOB (52% of patients) or higher SOB (48%) from POD1 to POD7. Estimated means (dashed lines) and observed means (solid lines) at each time point for all subgroups are plotted in Figure 2. In the two-group model, both groups demonstrated significantly linear and quadratic terms, with a mild symptom peak (mean 2.33, SD 2.17) at POD1 for the low group and a moderate symptom peak (mean 5.34, SD 2.61) for the high group (Figure 2). The Wilcoxon rank sum test showed that the difference in POD1 SOB between the low and high groups was significant (P < 0.001).

Figure 2

Trajectory for symptom of shortness of breath (SOB) in patients with lung cancer after surgery. *SOB severity in postoperative day 1 between low and high symptom group by Wilcoxon rank-sum test.

Optimal Cutpoints for SOB

Table 3 demonstrates the chi-square and p-values for the 9 sets of cutpoint (CP1 to CP9, ordered by the chi-square values). Using presence of PPCs as the anchor, CP6 and CP5 demonstrated the two highest Wald chi-square values. Among the 2000 samples of bootstrap resampling, 82.9% confirmed CP6 as the optimal cutpoint. (Table 4) Thus, we defined score < 6 as none/mild SOB and score (6 to 10) as severe SOB.

Table 3

Optimal Cutpoint Analysis Using Anchor of Postoperative Pulmonary Complications

Cutpoint	Postoperative Pulmonary Complications
	χ2 value	P
6	9.054	0.003
5	5.856	0.016
2	3.426	0.064
3	3.328	0.068
4	3.156	0.076
1	1.458	0.227
9	0.172	0.678
7	0.156	0.693
8	0.073	0.787

Table 4

Bootstrap with 2000 Resamplings for Cutpoints of Shortness of Breath

Cutpoint	Postoperative Pulmonary Complication
	χ2 value	95% CI	% as the Largest
5	3.726	3.577–3.876	17.1
6	6.569	6.349–6.789	82.9

Validating the Cutpoint of SOB

On day 1 after surgery, compared with patients reporting none/mild SOB, those severe SOB scores reported more symptom interference of general activity [median (IQR), 7 (3–9) vs 4 (1–7), P < 0.001], work [9 (3–10) vs 6 (1–10), P < 0.05], walking [8.5 (5–10) vs 5 (2–9), P < 0.001], mood [5 (1–8) vs 1 (0–4), P < 0.001], relations with others [6 (1–9) vs 2 (0–5), P < 0.001], and enjoyment of life [1 (0–6) vs 0 (0–2), P < 0.001] (Figure 3).

Figure 3

MDASI-LC symptom interference in different shortness of breath severity levels using the identified optimal cutpoint 6.

Longitudinally, patients with none/mild SOB experienced significantly less symptom interference with daily functioning (general activity, work, walking, mood, relations with others and enjoyment of life) during first 7 days after surgery than those in the severe SOB group (all P < 0.05) (Figure 4).

Figure 4

Change in average MDASI-LC interference ratings during one-week after surgery by SOB severity.

The severity of PPCs had a positive correlation with PLOS (r=0.64, P < 0.001). As shown in , the median PLOS for patients with severe SOB was 7 (95% CI=6-7), which was significantly higher than those who reported none/mild SOB (6 [95% CI=6-7], P = 0.007).

Discussion

For the first time, our analysis demonstrated that patient reported-SOB on POD1 was related to the onset of PPCs in patients with LC surgery, and half of the patients reported a high level of SOB during hospitalization. Using the presence of PPCs as an anchor, we then determined and validated that the optimal cutpoint of SOB for alerting PPCs is 6 on the 0–10 numeric scale. This cutpoint might serve as the threshold when using POD1 SOB to identify patients who might experience PPCs after lung cancer surgery. Our result supported that using the PRO-based SOB on POD1 can alert PPCs after thoracic surgery with the optimal threshold of 6.

Lung cancer resection is associated with a considerable risk of postoperative pulmonary complications (PPCs), which have a significant health and economic impact on patients and health care services.42 The PPCs need a multidisciplinary approach and careful monitoring to optimize the survival and quality of life of LC patients.43 For decades, efforts to decrease the incidence of PPCs have started with a comprehensive preoperative risk assessment.11 Various risk factors associated with PPCs and prediction models have been identified to aid in predicting PPCs. For example, preoperative pulmonary function tests were regarded as the potential risk factors for PPCs.44 Consistent with previous studies,2,33 we found that male and lower FEV1 were significantly associated with PPCs. These significant associations may due to smoking, because most smokers were male in our study. It has been reported that smoking as one of well-known risk factors for lung cancer and persistent cigarette exposure had a negative effect on lung function with spirometric parameters decreased and exercise performance of patients impaired.45

In recent years, numerous studies have established corresponding clinical scores based on these risk factors, which can quickly determine the degree of risk for a patient to develop PPCs.46 By adding PROs to traditional factors, our study showed that POD1 SOB was related to PPCs during hospitalization. Similarly, for patients following upper abdominal surgery, preoperative SOB was associated with the development of severe respiratory complications.47 For a busy surgical department, PRO-measured SOB may provide a feasible and interpretable method to identify those patients who have a risk of the occurrence of PPCs after lung surgery.

Symptoms of SOB, fatigue, and pain were commonly reported by patients with LC surgery, even though they suffered from SOB after completion of therapy.48 In our study, the two-group GBTM demonstrated that although all patients started with a low SOB symptom burden, more than half of the patients reported significantly more severe SOB symptoms during hospitalization, peaking on POD1. In addition, SOB could interfere with patients’ activities of daily living, with more symptom interference occurring as symptom severity increases.49 Cheville et al described that symptom of dyspnea was strongly associated with poor clinical outcomes (ie, employment status, physical activity, and overall QoL) in LC survivors.8 These results suggested that routine and proactive monitoring of the presence and severity of SOB as early as possible might be needed in practice. Adequate assessment and cutpoint-assisted interpretation of patient-reported SOB will support on-time patient care and promote optimal outcomes in the clinic.

Several symptom management guidelines have been developed based on symptom ratings so far, typically including severity thresholds. The National Comprehensive Cancer Network (NCCN) suggests that clinical attention was needed when these scores of symptoms, such as pain, fatigue, and distress, were rated ≥ 4 on a 0–10 scale.50 Our study suggested that 6 was the optimal cutpoint of SOB on POD1 for identifying patients who might develop PPCs after LC surgery. Selby et al used a receiver operating characteristic (ROC) curve, and the severity of SOB expressed on a verbal scale as a reference reported CP6 for severe SOB.51 The results are comparable to the cutoff values recorded in our study, although Selby et al used a verbal scale with patient options of none, mild, moderate, or severe as the anchor to determine cutpoints of symptoms in patients with palliative care.

Investigations have also used anchor-based methods to describe grades of symptom severity as the basis for establishing cutpoints between mild, moderate, and severe levels for various symptoms.52 Although there is no overall recommendation for choosing the anchors for the determination of cutpoints, the symptom interference items of the MDASI are usually used as anchors for symptom severity items, such as pain and fatigue.53,54 However, we used PPCs as the anchor in our study for the purpose of generating a clinically meaningful cutpoint for the early alerting of PPCs. The anchor (PPCs) we used significantly correlated with postoperative length of stay, which is commonly used in oncology practice for reflecting surgical skill and quality of care.55 Development of any PPCs, even if mild, is associated with reduced survival, prolonged stay in the hospital and increased in-hospital mortality.56 Additionally, our analysis demonstrated that the CP6-defined severe SOB level was associated with higher MDASI-LC symptom interference levels, suggesting that CP6 can be interpreted for functional impairment, similar as the pain and fatigue cutpoints anchored on the MDASI symptom interference.

This study had several limitations. First, few lung cancer patients underwent open surgery, resulting in a lower frequency of PPCs, which may preclude the observation of a large group in a timely manner and affect the comparability and generalization of the study results. However, VATs have been increasingly applied for LC surgery during the past 10 years,57 and recent report showed the proportion of VATs was reached 74.9% in LC patients,58 suggesting that this result can be interpreted for current clinical practice. Second, we used an anchor-based method to find the optimal cutpoint considering the relation between symptom severity and PPCs. Choosing different anchors and methods in other patient cohorts might produce different “optimal” cutpoint and variability in optimal cutpoint is to be expected,59 depending on the purpose of the test in a specific context as well as the costs of misses and false alarms.60 Third, we only used internal samples to validate the cutpoint of SOB but lacked external validation. External validation of the SOB cutpoint generated from our study is needed for a more generalized interpretation. Finally, we used 0–10 scale to measure dyspnea instead of using mMRC or TDI, further validation of our results are needed with those commonly used measurements.

Conclusion

In summary, the current analysis identified high POD1 dyspnea score (the patient-reported SOB), low FEV1, male and open surgery as predictive factors to the onset of PPCs after lung cancer surgery. The clinically meaningful cutpoint of SOB might facilitate the future evaluation of risk for PPCs, improve postoperative patient care and decrease clinician burden.