Gold-based hybrid nanostructures: more than just a pretty face for combinational cancer therapy.

The early diagnosis together with an efficient therapy of cancer is essential to treat cancer patients and to enhance their quality of life. The use of nanostructures, as a newer technology, has demonstrated proven benefits as efficient cancer theranostic agents in numerous recent studies. Having a tunable surface plasmon resonance, gold nanostructures have been the subject of many recent studies as excellent imaging and photothermal therapy agents. However, the potential cytotoxicity and weak stability of gold nanostructures necessitate further modifications using biocompatible materials for biological applications. Based on the composition of the final structure, these gold-based hybrid nanostructures (GHNs) could be divided into five major groups; each of which has specific pros and cons. Understanding the strengths and weaknesses of each group helps scientists to optimize GHN designs with multiple functions by synergizing the benefits of different groups. This review aims to summarize the advancements in GHN design and provide a perspective view of future requirements for successful GHN-based targeted combinational cancer theranostic platforms. © International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2021.