Literature DB >> 3533720

[Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine].

Iu I Pavlov.   

Abstract

Yeast mutants hypersensitive to the mutagenic action of 6-N-hydroxylaminopurine (HAP) were obtained by EMS mutagenesis. One of the mutants segregated monogenically and possessed reduced capacity to utilize HAP as a purine source. A set of diploids suitable for parallel study of mutagenesis and induction of recombination, and differing in the trait of mutability after exposure to HAP ("hm" trait or HAP mutability), were constructed. It was shown that a weak recombinogenic effect of HAP is not enhanced in "hm" mutants when HAP mutability increases.

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Year:  1986        PMID： 3533720

Source DB:  PubMed          Journal:  Genetika        ISSN： 0016-6758


  7 in total

1.  Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

Authors:  Elena I Stepchenkova; Elena R Tarakhovskaya; Kathryn Spitler; Christin Frahm; Miriam R Menezes; Peter D Simone; Carol Kolar; Luis A Marky; Gloria E O Borgstahl; Youri I Pavlov
Journal:  J Mol Biol       Date:  2009-07-23       Impact factor: 5.469

Review 2.  Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.

Authors:  Irina S-R Waisertreiger; Victoria G Liston; Miriam R Menezes; Hyun-Min Kim; Kirill S Lobachev; Elena I Stepchenkova; Tahir H Tahirov; Igor B Rogozin; Youri I Pavlov
Journal:  Environ Mol Mutagen       Date:  2012-10-10       Impact factor: 3.216

3.  Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.

Authors:  Irina S-R Waisertreiger; Miriam R Menezes; James Randazzo; Youri I Pavlov
Journal:  J Nucleic Acids       Date:  2010-09-26

4.  Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells.

Authors:  Miriam Rose Menezes; Irina S-R Waisertreiger; Hernando Lopez-Bertoni; Xu Luo; Youri I Pavlov
Journal:  PLoS One       Date:  2012-02-27       Impact factor: 3.240

5.  Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.

Authors:  Elena I Stepchenkova; Stanislav G Kozmin; Vladimir V Alenin; Youri I Pavlov
Journal:  BMC Genet       Date:  2005-06-02       Impact factor: 2.797

6.  Comment on "A commensal strain of Staphylococcus epidermidis protects against skin neoplasia" by Nakatsuji et al.

Authors:  Stanislav G Kozmin; Igor B Rogozin; Elizabeth A Moore; Mariah Abney; Roel M Schaaper; Youri I Pavlov
Journal:  Sci Adv       Date:  2019-09-11       Impact factor: 14.136

7.  Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.

Authors:  Artem G Lada; Elena I Stepchenkova; Irina S R Waisertreiger; Vladimir N Noskov; Alok Dhar; James D Eudy; Robert J Boissy; Masayuki Hirano; Igor B Rogozin; Youri I Pavlov
Journal:  PLoS Genet       Date:  2013-09-05       Impact factor: 5.917
  7 in total

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