| Literature DB >> 3533419 |
S Rowlands, A A Kubba, J Guillebaud, W Bounds.
Abstract
Twenty-seven women requesting postcoital contraception were randomly allocated to take an ethinylestradiol/dl-norgestrel combination or danazol. Urine specimens were assayed for luteinising hormone (LH) and pregnanediol-3-glucuronide (P3G) levels from the day of the postcoital treatment to the next period. In addition, the urine samples of these recruits and 12 additional women were assayed for the Beta-subunit of human chorionic gonadotropin (B-hCG). A consistent pattern of alteration in urinary steroids was lacking, indicating a heterogeneous effect on ovarian function. There was no evidence of early pregnancy in successfully treated cases. We suggest that the main mechanism of action of these drugs is at the endometrial level.Entities:
Keywords: Biology; Cervical Mucus--analysis; Cervix; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Postcoital; Contraceptive Agents, Progestin; Contraceptive Methods--pharmacodynamics; Endocrine System; Endometrium--changes; Ethinyl Estradiol; Examinations And Diagnoses; Family Planning; Fertility Control, Postcoital; Genitalia; Genitalia, Female; Gonadotropins; Gonadotropins, Chorionic--analysis; Gonadotropins, Pituitary; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Luteinizing Hormone--analysis; Menstrual Cycle--changes; Menstruation; Oral Contraceptives--pharmacodynamics; Physiology; Reproduction; Urogenital System; Uterus
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Year: 1986 PMID： 3533419 DOI： 10.1016/0010-7824(86)90042-9
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375