Aki Tabata1, Hiroki Yabe2, Takehide Katogi3, Tomoya Yamaguchi4, Yuya Mitake3, Oono Shunta3, Tomohiro Shirai3, Takayuki Fujii5. 1. Department of Rehabilitation, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura-shi, Chiba, 285-8765, Japan. tabata4107@gmail.com. 2. Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, 3453Mikatahara, Kita-ku, Hamamatsu, Shizuoka, 433-8558, Japan. 3. Department of Rehabilitation, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura-shi, Chiba, 285-8765, Japan. 4. Department of Rehabilitation, Seirei Fukuroi Municipal Hospital, 2515-1, Kuno, Fukuroi, Shizuoka, Japan. 5. Department of Nephrology, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura-shi, Chiba, 285-8765, Japan.
Abstract
BACKGROUND: Health-related quality of life (HRQoL) assessment is important for patients with chronic kidney disease (CKD). However, few studies have examined factors related to HRQoL, such as physical function, in older patients with predialysis CKD. This study evaluated the relationship between physical function, renal function, and nutritional status on the HRQoL in this patient group. METHODS: This cross-sectional study included 61 patients aged ≥ 65 years with stages 3-5 predialysis CKD who were admitted for CKD education purposes. Using the EuroQoL 5-dimension 5-level (EQ-5D-5L) health status measure, the percentages of each EQ-5D-5L item were investigated. Physical function was measured using the short physical performance battery (SPPB) and grip strength, and characteristics, such as age, sex, diabetes mellitus, estimated glomerular filtration rate, and Geriatric Nutrition Risk Index, were investigated. Factors associated with EQ-5D-5L were identified using multiple regression analysis. RESULTS: More than half of respondents (34/61, 55.7%) selected the second or higher level "have a problem" for the pain/discomfort section. The EQ-5D-5L score was significantly correlated with grip strength (r = 0.34, p = 0.01) and SPPB (r = 0.59, p = 0.00) in a single correlation analysis. Only SPPB (β = 0.67, p = 0.00) remained a significant factor after adjustment for grip strength, SPPB, age, sex, diabetes mellitus, and estimated glomerular filtration rate. CONCLUSION: Physical function may be an important factor influencing HRQoL in older patients with predialysis CKD.
BACKGROUND: Health-related quality of life (HRQoL) assessment is important for patients with chronic kidney disease (CKD). However, few studies have examined factors related to HRQoL, such as physical function, in older patients with predialysis CKD. This study evaluated the relationship between physical function, renal function, and nutritional status on the HRQoL in this patient group. METHODS: This cross-sectional study included 61 patients aged ≥ 65 years with stages 3-5 predialysis CKD who were admitted for CKD education purposes. Using the EuroQoL 5-dimension 5-level (EQ-5D-5L) health status measure, the percentages of each EQ-5D-5L item were investigated. Physical function was measured using the short physical performance battery (SPPB) and grip strength, and characteristics, such as age, sex, diabetes mellitus, estimated glomerular filtration rate, and Geriatric Nutrition Risk Index, were investigated. Factors associated with EQ-5D-5L were identified using multiple regression analysis. RESULTS: More than half of respondents (34/61, 55.7%) selected the second or higher level "have a problem" for the pain/discomfort section. The EQ-5D-5L score was significantly correlated with grip strength (r = 0.34, p = 0.01) and SPPB (r = 0.59, p = 0.00) in a single correlation analysis. Only SPPB (β = 0.67, p = 0.00) remained a significant factor after adjustment for grip strength, SPPB, age, sex, diabetes mellitus, and estimated glomerular filtration rate. CONCLUSION: Physical function may be an important factor influencing HRQoL in older patients with predialysis CKD.
Authors: Lesley A Stevens; Suying Li; Changchun Wang; Cindy Huang; Bryan N Becker; Andrew S Bomback; Wendy Weinstock Brown; Nilka Ríos Burrows; Claudine T Jurkovitz; Samy I McFarlane; Keith C Norris; Michael Shlipak; Adam T Whaley-Connell; Shu-Cheng Chen; George L Bakris; Peter A McCullough Journal: Am J Kidney Dis Date: 2010-03 Impact factor: 8.860
Authors: Anna C Porter; James P Lash; Dawei Xie; Qiang Pan; Jennifer DeLuca; Radhika Kanthety; John W Kusek; Claudia M Lora; Lisa Nessel; Ana C Ricardo; Julie Wright Nunes; Michael J Fischer Journal: Clin J Am Soc Nephrol Date: 2016-05-31 Impact factor: 8.237
Authors: Karin Windahl; Gerd Faxén Irving; Tora Almquist; Maarit Korkeila Lidén; Moniek van de Luijtgaarden; Nicholas C Chesnaye; Pauline Voskamp; Peter Stenvinkel; Marian Klinger; Maciej Szymczak; Claudia Torino; Maurizio Postorini; Christiane Drechsler; Fergus J Caskey; Christoph Wanner; Friedo W Dekker; Kitty J Jager; Marie Evans Journal: J Ren Nutr Date: 2018-02-16 Impact factor: 3.655
Authors: Agneta A Pagels; Birgitta Klang Söderkvist; Charlotte Medin; Britta Hylander; Susanne Heiwe Journal: Health Qual Life Outcomes Date: 2012-06-18 Impact factor: 3.186
Authors: Olalekan Lee Aiyegbusi; Derek Kyte; Paul Cockwell; Tom Marshall; Adrian Gheorghe; Thomas Keeley; Anita Slade; Melanie Calvert Journal: PLoS One Date: 2017-06-21 Impact factor: 3.240
Authors: Moniek C M de Goeij; Gurbey Ocak; Joris I Rotmans; Jan-Willem Eijgenraam; Friedo W Dekker; Nynke Halbesma Journal: PLoS One Date: 2014-04-03 Impact factor: 3.240