| Literature DB >> 35332263 |
Yoshiaki Abe1, Mamiko Sakata-Yanagimoto2,3,4, Manabu Fujisawa5, Hiroaki Miyoshi6, Yasuhito Suehara7, Keiichiro Hattori7, Manabu Kusakabe5,7, Tatsuhiro Sakamoto5,7, Hidekazu Nishikii5,7, Tran B Nguyen5, Yohei Owada8, Tsuyoshi Enomoto8, Aya Sawa9, Hiroko Bando10, Chikashi Yoshida11, Rikako Tabata12, Toshiki Terao12, Masahiro Nakayama13, Koichi Ohshima6, Kensuke Usuki14, Tatsuya Oda8, Kosei Matsue12, Shigeru Chiba15,16.
Abstract
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our understanding of lymphoma NHCs has been hampered by unexplained NHC heterogeneity, even in normal human lymph nodes (LNs). Here we constructed a single-cell transcriptome atlas of more than 100,000 NHCs collected from 27 human samples, including LNs and various nodal lymphomas, and it revealed 30 distinct subclusters, including some that were previously unrecognized. Notably, this atlas was useful for comparative analyses with lymphoma NHCs, which revealed an unanticipated landscape of subcluster-specific changes in gene expression and interaction with malignant cells in follicular lymphoma NHCs. This facilitates our understanding of stromal remodelling in lymphoma and highlights potential clinical biomarkers. Our study largely updates NHC taxonomy in human LNs and analysis of disease status, and provides a rich resource and deeper insights into LN and lymphoma biology to advance lymphoma management and therapy.Entities:
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Year: 2022 PMID： 35332263 PMCID： PMC9033586 DOI： 10.1038/s41556-022-00866-3
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.213