| Literature DB >> 35324310 |
Wenkang Chen1, Lu Chen2, Xuan Zhang1, Ning Yang2,3, Jianghua Guo1, Min Wang1, Shenghui Ji1, Xiangyu Zhao1, Pengfei Yin1, Lichun Cai1, Jing Xu1, Lili Zhang1, Yingjia Han1, Yingni Xiao1, Gen Xu1, Yuebin Wang2, Shuhui Wang1, Sheng Wu1, Fang Yang2,3, David Jackson2,4, Jinkui Cheng1,5, Saihua Chen6, Chuanqing Sun1, Feng Qin1,5, Feng Tian1,5, Alisdair R Fernie7, Jiansheng Li1,5, Jianbing Yan2,3, Xiaohong Yang1,5.
Abstract
A better understanding of the extent of convergent selection among crops could greatly improve breeding programs. We found that the quantitative trait locus KRN2 in maize and its rice ortholog, OsKRN2, experienced convergent selection. These orthologs encode WD40 proteins and interact with a gene of unknown function, DUF1644, to negatively regulate grain number in both crops. Knockout of KRN2 in maize or OsKRN2 in rice increased grain yield by ~10% and ~8%, respectively, with no apparent trade-offs in other agronomic traits. Furthermore, genome-wide scans identified 490 pairs of orthologous genes that underwent convergent selection during maize and rice evolution, and these were enriched for two shared molecular pathways. KRN2, together with other convergently selected genes, provides an excellent target for future crop improvement.Entities:
Mesh：
Substances：
Year: 2022 PMID： 35324310 DOI： 10.1126/science.abg7985
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714